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Atherosclerotic plaque investigation, by ultrasound and optical tomography

Grant number: 12/15721-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): January 01, 2013
Effective date (End): October 31, 2013
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal Investigator:Sergio Shiguemi Furuie
Grantee:Matheus Cardoso Moraes
Host Institution: Escola Politécnica (EP). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Atherosclerosis cause the death of millions of people annually around the world, and produces billions in expenses, the biggest among all illnesses. It is given by the accumulation of plaques, lipidic, fibrous, and calcified tissue in the coronary wall, which may cause heart attack, or cardiac death. The lipidic plaques are the most dangerous with the highest elasticity, whereas the calcified and fibrous are more stable and less elastic, which can be treated by stents. However, the stent treatment may lead to a neo-intima re-stenosis. The Intravascular Ultrasound (IVUS), and Optical Coherent Tomography Intravascular (IOCT) are reference medical images modalities for diagnostics and to follow treatment progression. Nonetheless, a lot of information from the mentioned modalities may be obtained quantitatively, by segmentation, feature extraction, such as texture. In addition, by working with these images dynamically, mechanical properties can be extracted. The additional information led to more precise diagnostics, therapy planning, and treatment progression supervisions. Therefore, we propose to create a combination of methods, such as segmentation, feature extraction, 3D reconstruction to support and increase precision of atherosclerotic plaques characterization, and neo-intima re-stenosis supervision. Finally, the evaluation will be carried out by numerical and physical phantoms, and real images with corresponding virtual histology.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MORAES, MATHEUS CARDOSO; CARDONA CARDENAS, DIEGO ARMANDO; FURUIE, SERGIO SHIGUEMI. Automatic lumen segmentation in IVOCT images using binary morphological reconstruction. BIOMEDICAL ENGINEERING ONLINE, v. 12, . (12/15721-2)
FERNANDO MITSUYAMA CARDOSO; MATHEUS CARDOSO MORAES; SERGIO SHIGUEMI FURUIE. Realistic deformable 3D numeric phantom for transcutaneous ultrasound. Res. Biomed. Eng., v. 33, n. 1, p. 1-10, . (12/15721-2, 11/01314-3)

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