Advanced search
Start date
Betweenand

FUNCTIONAL STUDY OF THE CO-CHAPERONE STI1 IN MURINE EMBRYONIC STEM CELL BIOLOGY

Grant number: 12/15014-4
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2012
Effective date (End): September 30, 2014
Field of knowledge:Biological Sciences - Biology
Principal researcher:Marilene Hohmuth Lopes
Grantee:Jenny Andrea Arévalo Romero
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:11/13906-2 - Contribution of the co-chaperone STI1 in mouse development: embryonic stem cell as approach, AP.JP

Abstract

STI1 (Stress inducible protein 1) is a co-chaperone that have wide functional versatility mediating important neuronal functions as differentiation and proliferation in astrocytes, neuroprotection and memory consolidation acting independently or in partnership with other molecules. Recent studies demonstrate a central role for STI1 in control of proliferation and self-renewal of neural stem cells and in the regulation of nuclear translocation of STAT3 (signal transducer and activator of transcription 3) in embryonic stem cells, suggesting the involvement of STI1 in the pluripotency status. In fact, the group demonstrated a fundamental role of STI1 in mammalian development through the construction of a constitutive knockout animal for STI1, which was developed until the tenth day of embryonic life. Given this data, the study of embryonic stem cells derived from mice with genotypes like wild-type genotype (STI1wt/wt), heterozygous genotype (STI1wt/ko) and deficient genotype for STI1 (STI1ko/ko) becomes the most appropriate experimental model to evaluate the functions performed by STI1 in mammalian developmental biology.

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)