Advanced search
Start date
Betweenand

Influence of pulpal infection alone or associated with diabetes in the quantification of proinflammatory cytokine IL-17 in periapical lesions and organs of rats.

Grant number: 12/02565-2
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2012
Effective date (End): April 30, 2014
Field of knowledge:Health Sciences - Dentistry - Endodontics
Principal researcher:Luciano Tavares Angelo Cintra
Grantee:Mariane Maffei Azuma
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

This study will evaluate the influence of pulpal infection alone or associated with diabetes in the quantification of proinflammatory cytokine IL-17 in periapical lesions and organs of rats. Will be used 40 mice divided into four groups of 10 animals: G1 - normal rats, G2 - rats with periapical lesion, G3 - diabetic rats, G4 - diabetic rats with pulpal infection. Diabetes is induced by application of streptozotocin intravenously and confirmed in 24/48 hours subsequent evaluation by glucose. The periapical lesion is induced by exposure of the maxillary right first molar to the oral environment. After 30 postoperative days the animals will be sacrificed. The heart, liver and kidneys of all animals, as well as periapical lesions of groups 2 and 4 are removed. Will be used the ELISA to quantify the proinflammatory cytokine IL-17 in periapical lesions in animal bodies. The results are analyzed and compared in terms of statistical significance level of 5% (p <0.05).

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AZUMA, MARIANE MAFFEI; GOMES-FILHO, JOAO EDUARDO; CARRARA PRIETO, ANNELISE KATRINE; SAMUEL, RENATA OLIVEIRA; FELIX DE LIMA, VALERIA MARCAL; SUMIDA, DORIS HISSAKO; ERVOLINO, EDILSON; ANGELO CINTRA, LUCIANO TAVARES. Diabetes increases interleukin-17 levels in periapical, hepatic, and renal tissues in rats. ARCHIVES OF ORAL BIOLOGY, v. 83, p. 230-235, NOV 2017. Web of Science Citations: 5.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
AZUMA, Mariane Maffei. Influência da infecção endodôntica associada ou não à diabetes nos níveis da citocina pró-inflamatória IL-17 nos tecidos periapical, hepático e renal de ratos Wistar. 2014. 68 f. Master's Dissertation - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Odontologia (Campus de Araçatuba)..

Please report errors in scientific publications list by writing to: cdi@fapesp.br.