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Fibroblast Growth factors (FGFs)and bone morphogenetic protein 15 (BMP15) on in the diferentiation of bovine cumulus cells.

Grant number: 12/15820-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2016
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:José Buratini Junior
Grantee:Paula Fernanda de Lima
Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Our group has recently demonstrated that fibroblast growth factors (FGFs) expressed by the oocyte stimulate cumulus expansion and regulate the expression of genes that regulate this process. This proposal aims to investigate in greater depth the functions of FGFs 2, 10 and 17 and BMP15 in the regulation of cumulus cells differentiation in cattle. To accomplish the overall objective, we will test the effects of FGFs, BMP15 and FGFs combined with BMP15 on cumulus expansion, apoptosis, production of steroids (estradiol and progesterone) and energy metabolism in "oocytectomized" COCs via aspiration of the oocyte content. To gain insight into the underlying mechanisms, the effects of these treatments on the expression of genes known to be involved in the control of the affected parameters will be analyzed. The removal of the oocyte aims to abolish the influence of factors secreted in the intact COC that can potentially confound the effects of the treatments. Additionally, to investigate whether FGFs may in fact regulate in paracrine or autocrine manners the differentiation of cumulus cells, we will test the hypothesis that bovine COCs secrete FGFs 2, 10 and 17 and that secretion is regulated by FSH.

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Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
LIMA, Paula Fernanda de. The effects of oocyte secreted factors (OSF) on the differentiation of cumulus cells during in vitro maturation (IVM) in cattle. 2016. Doctoral Thesis - Universidade Estadual Paulista (UNESP). Instituto de Biociências. Botucatu Botucatu.

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