Effect of aerobic exercise training on vasomotor response of ovariectomized rats.

• Grant number: 12/17709-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: November 01, 2012
• End date: February 28, 2014
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Ricardo Jose Gomes
• Grantee: Viviane Aparecida Vieira Nogueira Braga
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

The postmenopausal women lose their cardiovascular protection due to reduced levels of estrogen. A woman loses her postmenopausal cardiovascular protection due to reduced levels of estrogen. This reduction is related to the increased production of free radicals with reduction of the production of nitric oxide bioavailability and, with increased vascular resistance and consequently with endothelial dysfunction factors that contribute to the development of hypertension. Thus, studies have tried to find an alternative way to minimize changes triggered by estrogen deficiency in postmenopausal women. Research has demonstrated the benefits of physical exercise as a non-pharmacological treatment can minimize or even reverse these changes. Exercise training promotes a post-exercise hypotension, elevated expression of antioxidant enzymes, increasing the bioavailability of nitric oxide (NO) production and to vessels, increased endothelium-dependent vasodilation induced by acetylcholine, reduce peripheral vascular resistance which leads hence improvement in endothelial function. However, the effect of exercise training in postmenopausal period presents little known answers, so the aim of this study is to evaluate the effects of aerobic exercise training (treadmill) on the vasomotor response (swelling) in aorta of ovariectomized rats, highlighting the role of NO and reactive oxygen species.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BRAGA, VIVIANE A. V. N.; COUTO, GISELE K.; LAZZARIN, MARIANA C.; ROSSONI, LUCIANA V.; MEDEIROS, ALESSANDRA. Aerobic Exercise Training Prevents the Onset of Endothelial Dysfunction via Increased Nitric Oxide Bioavailability and Reduced Reactive Oxygen Species in an Experimental Model of Menopause. PLoS One, v. 10, n. 4, APR 29 2015. (12/17709-0, 10/50048-1)