|Support type:||Scholarships in Brazil - Scientific Initiation|
|Effective date (Start):||November 01, 2012|
|Effective date (End):||October 31, 2013|
|Field of knowledge:||Physical Sciences and Mathematics - Chemistry - Organic Chemistry|
|Principal Investigator:||Leandro Helgueira de Andrade|
|Grantee:||Felipe Zottino Nazareth|
|Home Institution:||Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil|
The purpose of this project is the chemo-enzymatic synthesis of boronic amino esters from their hydroxy-boronic precursors. A key step using enzymatic kinect resolution (KR) of alcohols will be applied to obtain both enantiomeric forms. Lipase-B of Candida antarctica (CAL-B) was the biological catalyst chosen for the KR process. Besides, chiral azides will be prepared and used as starting materials to triazoles.