Chemoenzymatic synthesis of chiral boronic amino esters.

• Grant number: 12/19195-3
• Support type: Scholarships in Brazil - Scientific Initiation
• Effective date (Start): November 01, 2012
• Effective date (End): October 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Leandro Helgueira de Andrade
• Grantee: Felipe Zottino Nazareth
• Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The purpose of this project is the chemo-enzymatic synthesis of boronic amino esters from their hydroxy-boronic precursors. A key step using enzymatic kinect resolution (KR) of alcohols will be applied to obtain both enantiomeric forms. Lipase-B of Candida antarctica (CAL-B) was the biological catalyst chosen for the KR process. Besides, chiral azides will be prepared and used as starting materials to triazoles.