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Chemoenzymatic synthesis of chiral boronic amino esters.

Grant number: 12/19195-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2013
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Leandro Helgueira de Andrade
Grantee:Felipe Zottino Nazareth
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The purpose of this project is the chemo-enzymatic synthesis of boronic amino esters from their hydroxy-boronic precursors. A key step using enzymatic kinect resolution (KR) of alcohols will be applied to obtain both enantiomeric forms. Lipase-B of Candida antarctica (CAL-B) was the biological catalyst chosen for the KR process. Besides, chiral azides will be prepared and used as starting materials to triazoles.