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Role of altered glutamatergic neurotransmission in acute liver failure (ALF).

Grant number: 12/15660-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2015
Field of knowledge:Health Sciences - Medicine
Principal researcher:Alan Stewart Hazell
Grantee:Vinícius Rodrigues Silva
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The present study aimed primarily to see if there are changes on the expression of glutamate receptors and their contribution to increasing the extracellular concentration of glutamate and its effect on neurological dysfunction in mice with acute liver failure induced by Azoxymethane, the second objective is to determine this the influence of glutamate depolarization of nerve cells in mice with severe acute exacerbated by varying the ammonia concentration is a factor that influences the depolarization of nerve cells, causing a greater disease in dysfunction.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, VINICIUS R.; SECOLIN, RODRIGO; VEMUGANTI, RAGHU; LOPES-CENDES, ISCIA; HAZELL, ALAN S. Acute liver failure is associated with altered cerebral expression profiles of long non-coding RNAs. Neuroscience Letters, v. 656, p. 58-64, AUG 24 2017. Web of Science Citations: 4.
VEMUGANTI, RAGHU; SILVA, VINICIUS R.; MEHTA, SURESH L.; HAZELL, ALAN S. Acute liver failure-induced hepatic encephalopathy is associated with changes in microRNA expression profiles in cerebral cortex of the rat. METABOLIC BRAIN DISEASE, v. 29, n. 4, SI, p. 891-899, DEC 2014. Web of Science Citations: 7.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SILVA, Vinícius Rodrigues. Alterations in the frontal cortex of mice male C57BL mice with acute liver failure induced azoxymethane : analyzes of long noncoding RNAs and microRNAs. 2016. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.

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