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Medication effects on cardiac autonomic modulation in children with attention deficit hyperactivity disorder

Grant number: 12/09147-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2012
Effective date (End): October 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal researcher:Luiz Carlos de Abreu
Grantee:Pâmela Spina Capitão
Home Institution: Faculdade de Medicina do ABC (FMABC). Organização Social de Saúde. Fundação do ABC. Santo André , SP, Brazil


Introduction: Attention deficit hyperactivity disorder (ADHD) is characterized by lack of attention, impulsivity, and excessive motor activity. ADHD is based on genetic factors and reaches 3% to 7% of the population. To minimize the symptoms of ADHD, different methods has been used such as medication, speech therapists, psycho-pedagogical among others. The most common drugs used are stimulants such as methylphenidate. However, this type of medication can cause cardiotoxiceffectsand and cardiatic conduction disturbances. Therefore, it is necessary to investigate changes in autonomic modulation of ADHD patients under drug treatment. Objective: To compare the cardiatic autonomic modulation in children with ADHD with and without drug treatment through analysis of heart rate variability (HRV). Method: It will be realized a cross sectional study, with twenty-five children from five to twelve years old, all users of the Núcleo Especializado em Aprendizagem in FMABC in the period of June to December 2012. The biological characteristics studied are weight, height, body composition and autonomic modulation. The study of the autonomic modulation is performed by analyzing linear levels (in the domain of time and frequency) and nonlinear levels (in the field of chaos) of heart rate variability.

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