Chemical study of EtOAc fraction from Anacardium othonianum Rizz. (Anacardiaceae) and schistosomicidal activity evaluation

• Grant number: 12/18060-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: December 01, 2012
• End date: November 30, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Patricia Mendonça Pauletti
• Grantee: Flávia Maria Lígia Marangoni Jordão Curado
• Host Institution: Coordenadoria Adjunta de Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil

Abstract

The Anacardiaceae consists of approximately 73 genera, which comprises 600 to more than 850 species, found in tropical and subtropical areas. Chemistry studies of Anacardium occidentale revealed the presence of phenolic lipids (anacardic acids) in the fruits and flavonoids and tannins in the leaves. Although, A. othonianum showed no phytochemical study. The search for new drugs for the treatment of tropical diseases, for example, antischistosomal, in general, is considered the lowest priority for Pharmaceutical companies. Thus, this project aims to realize the chemical study of the bioactive EtOAc fraction obtained from the leaves ethanolic crude extract of A. othonianum Rizz. (Anacardiaceae) and to evaluate the schistosomicidal activity of the isolated compounds. Additionally, it will contribute to human resource formation in the Franca region.(AU)