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Intracellular peptides changes in anterior temporal lobe schizophrenia

Grant number: 12/21573-6
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): January 15, 2013
Effective date (End): July 14, 2013
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Luiz Roberto Giorgetti de Britto
Grantee:Cecília Cequeira Café Mendes
Supervisor abroad: Christoph W. Turck
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Max Planck Society, Munich, Germany  
Associated to the scholarship:09/53515-2 - Analysis of oligopeptidases and intracellular peptides and their physiopathological implications in neurodegenerative diseases, BP.DR

Abstract

Neurological disorders include neurodegenerative and neuropsychiatric disorders, which are characterized, respectively, by progressive dysfunction with neuronal loss, and disorders in the processing, encoding and filtering of the incoming sensory information. Examples of these disorders are Parkinson's disease (PD), which is characterized by movement disturbances due to a decrease in dopaminergic inputs to the striatum as consequence of neuronal death in substantia nigra pars compacta (SNc), and schizophrenia (SCZ), in which the patients manifest hallucinations, delusions, thought disorder, as well as disturbances in social behavior, motivation and affectivity, among other symptoms. Studies have already correlated the role of peptides and oligopeptidases in the progression of Alzheimer's disease, PD and SCZ. In addition, data from our lab demonstrated a biological function for hemopressin in the modulation of cannabinoid receptors, recognized as important in regulating the development of those disorders. Taking this into account, the aim of the following project is to evaluate possible changes in intracellular peptides in anterior temporal lobe samples of SCZ patients and also specifically in hemopressin (PVNFKFLSH) and related peptides (VD-Hpalfa VDPVNFKLLSH, RVD-Hpalfa-RVDPVNFKLLSH, VD-Hpbeta). These issues will be evaluated by isotopic labeling and liquid chromatography associated to mass spectometer (LC-MS/MS) to quantify and identify such peptides. (AU)