Influence of the transcriptional dynamics on RNA folding

• Grant number: 12/19377-4
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): December 01, 2012
• Effective date (End): August 31, 2016
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal researcher: Ney Lemke
• Grantee: Pedro Rafael Costa
• Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Nucleic acids are targets of intense research since the late nineteenth century. In the mid-twentieth century, the Central Dogma of Molecular Biology presented a framework for the transfer of information between the biopolymers present in the intracellular space. Until the beginning of this century, the RNA was famous only for its role in Central Dogma. In recent years, studies have shown its catalytic and regulatory role in gene expression. The sequence and structure of a given RNA molecule will determine which chemical compound it will interact. Determine the conformation of this molecule in space is an important issue for molecular biology, since despite the evolution of sequencing, molecular structure determination methods still costly, laborious and restricted to small biopolymers. Bioinformatics tools and computational biology can significantly collaborate on understanding this phenomenon. However, traditional techniques perform the prediction of a "static" structure of the RNA. We propose an algorithm for cotranscriptional folding simulating, to study how the kinetics of transcription can modigy the structures of the RNA. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

COSTA, Pedro Rafael. Influence of the transcriptional dynamics on RNA folding. 2016. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Biociências. Botucatu Botucatu.