Neural mechanisms involved in purinergic signaling in the control of central and peripheral chemosensitivity

• Grant number: 12/10337-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: December 01, 2012
• End date: November 30, 2015
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Thiago dos Santos Moreira
• Grantee: Bárbara Falquetto
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 14/04866-5 - Role of P2Y1 receptors within the C1 neurons controlling breathing and blood pressure, BE.EP.DR

Abstract

Ventilation is a neural process essential for the homeostasis of the organism, which promotes the regulation of O2 and CO2 levels in blood and tissues. It is well established that central and peripheral chemoreceptors detect changes in the concentrations of arterial blood gases and transmit this information to cardiorespiratory centers that regulate ventilation and efferent sympathetic activity to generate adequate ventilation/perfusion to tissues. The deficiency in chemoreceptor activity is associated with numerous problems including obstructive sleep apnea, sudden death of the newborn, the congenital central hypoventilation syndrome and hypertension. However, the mechanism of cellular and molecular chemoreception and the integration of central and peripheral chemoreflex are not completely elucidated. Many regions are important in chemoreception, including the nucleus of the solitary tract (NTS) and retrotrapezoid nucleus (RTN). In the RTN, the mechanism of central chemoreception involves activation of chemosensitive neurons, which detect changes CO2/pH, possibly being modulated by purinergic signaling. Thus, the main objective of this project is seeking to identify the role of purinergic signaling in regions crucial for cardiorespiratory control (NTS and RTN) and possible involvement in the activation of central and peripheral chemoreflex in unanesthetized animals. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MOREIRA, THIAGO S.; WENKER, IAN C.; SOBRINHO, CLEYTON R.; BARNA, BARBARA F.; TAKAKURA, ANA C.; MULKEY, DANIEL K.. Independent purinergic mechanisms of central and peripheral chemoreception in the rostral ventrolateral medulla. JOURNAL OF PHYSIOLOGY-LONDON, v. 593, n. 5, p. 1067-1074, MAR 1 2015. (11/13462-7, 10/09776-3, 13/10573-8, 12/10337-0, 09/54888-7, 13/02350-9, 14/04866-5)

BARNA, B. F.; TAKAKURA, A. C.; MULKEY, D. K.; MOREIRA, T. S.. Purinergic receptor blockade in the retrotrapezoid nucleus attenuates the respiratory chemoreflexes in awake rats. ACTA PHYSIOLOGICA, v. 217, n. 1, p. 80-93, MAY 2016. (12/10337-0, 10/09776-3, 09/54888-7, 13/10573-8)