Schizophrenia and bipolar disorder (BD) are neurodevelopmental illnesses that cause an enormous burden of suffering, high morbidity and mortality rates. Both are complex diseases characterized by alteration in multiple genes, combined with epigenetic modifications and environmental factors. Since these disorders are diagnosed, the patients need care and treatment for the rest of their lives. Therefore, it is very important to study these disorders before transition to psychosis to better understand the pathophysiology of schizophrenia and BD, and also to find out biomarkers that can predict this transition. The aim of the present study is to analyze the gene expression of 28 mRNAs and 88 miRNAs related to neurotransmission in four groups: 80 health subjects; 80 patients in first episode of psychosis; and 80 subjects Ultra High Risk (UHR) for psychosis, 20 of them with DiGeorge syndrome. Besides, it is expected a transition rate of 25% to psychosis in a follow up of two years, in which we will also analyze the gene expression of mRNA and miRNA. The gene expression will be verified through Real Time qPCR technology. With this study, we expect to find differential expression of mRNA and miRNA, in order to discover new biomarkers of progression and transition to psychosis. To our knowledge, there is no such study investigating gene expression of mRNA or miRNA in a UHR sample.
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