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Study of migratory, effector and regulatory patterns of cell present in the central nervous system during the inflammatory process of Experimental Autoimmune Encephalomyelitis

Grant number: 12/21172-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2013
Effective date (End): March 31, 2016
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Alessandro dos Santos Farias
Grantee:Gleidy Ana Araujo Silva
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

The experimental auto-immune encephalomyelitis (EAE) is an autoimmune T cells mediated diseases, since this disease can be adoptively transferred to naive animals by T CD4 lymphocytes transfer. The effector function of these lymphocytes, however, can be decreased by regulatory T lymphocytes. On the other hand, the auto-reactive T lymphocytes as well as the regulatory T lymphocytes are identified within the T CD4 lymphocytes population. Therefore, the labeling of effectors T lymphocytes opens up a possibility of understanding the migration of these lymphocytes to the nervous system (central or peripheral), as well as the interaction between the auto-reactive and regulatory cells that co-migrate to attenuate the inflammation on the nervous system. In this study, we will use the GFP retroviral transduction technique in auto-reactive T lymphocytes. This method allows a permanent labeling, allowing in vitro, ex vivo and in vivo analysis of auto-reactive T lymphocytes, by cytometry flow and/or confocal microscopy. Besides that, this method of labeling will allow us the track of the auto-reactive T CD4 lymphocytes during its migration as well as cells that comygrate with encephalitogenic t cells into the CNS.

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