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High adhesive nanofibers membrane to oral delivery of drugs

Grant number: 12/11904-5
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): March 01, 2013
Effective date (End): March 31, 2016
Field of knowledge:Engineering - Chemical Engineering - Chemical Technology
Principal Investigator:Lucia Helena Innocentini Mei
Grantee:Silvia Vaz Guerra Nista
Home Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The mucosas (nasal, rectal, ocular, vaginal and buccal) are considered as potential sites for administration of drugs with several advantages over oral administration. Among the mucous membranes, the buccal, due to ease of administration, is the most widely accepted by patients, but presents great challenges for the administration of drugs. One of these challenges, which require great efforts from the scientific community, is the low efficiency of adhesive systems, the low efficiency of the controlled drug release and effect "burst release". Many mucoadhesive polymers were tested in systems in order to increase interaction and duration of contact between the polymer containing the drug and the mucosal surface, but many challenges still must be overcome. The use of electrospinning nanofiber membranes as carriers for pharmaceuticals agent, has shown a future broad biomedical applications, because the drugs can be conveniently incorporated into the polymer and the drug release profile can be designed for a modulation of the morphology, porosity and the membrane composition of nanofibers. In this design it is proposed to develop a system for oral delivery of drugs, based on the electrospinning nanofiber membranes from solutions of highly mucoadhesive polymers. In the scientific literature, until this time, no work has been described using mucoadhesive nanofiber membranes to release buccal drug. It is believed that the structure formed by three-dimensional network of nanofibers, with its high surface area will increase the interactions between the adhesive membrane and mucosa improving its performance as a device for controlled release.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GUERRA NISTA, SILVIA VAZ; BETTINI, JEFFERSON; INNOCENTINI MEI, LUCIA HELENA. Coaxial nanofibers of chitosan-alginate-PEO polycomplex obtained by electrospinning. Carbohydrate Polymers, v. 127, p. 222-228, AUG 20 2015. Web of Science Citations: 34.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
NISTA, Silvia Vaz Guerra. High adhesive nanofibers membrane for buccal drug delivery. 2016. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Engenharia Química.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.

Filed patent(s) as a result of this research project

PROCESSO DE OBTENÇÃO DE MEMBRANAS DE NANOFIBRAS DE ALGINATO/PEO MUCOADESIVAS DUPLAMENTE RETICULADAS, MEMBRANAS DE NANOFIBRAS E USO BR1020160172748 - Universidade Estadual de Campinas (UNICAMP) . Lucia Helena Innocentini Mei; Silvia Vaz Guerra Nista - July 2016, 26

PROCESSO DE OBTENÇÃO DE MEMBRANAS DE NANOFIBRAS DE ALGINATO/PEO MUCOADESIVAS DUPLAMENTE RETICULADAS, MEMBRANAS DE NANOFIBRAS E USO PCT/BR2017/000083 - Universidade Estadual de Campinas (UNICAMP) . Lucia Helena Innocentini Mei; Silvia Vaz Guerra Nista - July 2017, 28