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Mutagenic effect of air pollution and perception of quality of life in practicers physically active aerobics in open environment at Presidente Prudente/SP

Grant number: 12/22229-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2013
Effective date (End): December 31, 2013
Field of knowledge:Health Sciences - Physiotherapy and Occupational Therapy
Principal Investigator:Dionei Ramos
Grantee:Gabriel Faustino Santa Brígida
Home Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil


Air pollution is a topic widely discussed due to the harmful effects it causes to human health. In Brazil, the emission of air pollutants such as particulate matter (PM), toxic gases from industrial processes, flow of vehicles and biomass burning are responsible for the exposure of millions of people every year. Biomass burning is concentrated in São Paulo for being the largest producer of sugarcane in the country, and cities around the plants as Presidente Prudente, are influenced by pollutants generated by burning straw during harvest, which may increase the concentration levels of air pollution in this period in association with the vehicle pollution. Such pollution releases to atmosphere MP and chemicals that have mutagenic potential in individuals exposed, causing deleterious effects on health and may reduce the perception of quality of life of these individuals. The study objectives are to assess the mutagenic effects of air pollution and perception of quality of life in practicers aerobic physical activity in an open environment. The study will be conducted in the city of Presidente Prudente/SP between the months of February through July 2013. Participate in the study, 40 healthy subjects will be divided into two groups: the exposed group, composed of individuals who make aerobic physical activity in an open environment and control group of sedentary individuals who work indoors. All participants will be evaluated for mutagenicity using the micronucleus frequency in peripheral blood erythrocytes and perception of quality of life using the SF-36 short version. Participants also perform a blood test for the quantification of blood cells. During the evaluation of air pollution will be determined by the sampler active particles, medium volume, portable Handi-VOL and analyzed by reflectance and fluorescence X-rays. A descriptive statistical analysis will be used for the clinical characterization of subjects studied and the distribution of the data will be evaluated by the Shapiro-Wilk. The data will be analyzed using parametric variance for repeated measures followed by the Tukey test. For nonparametric data will apply the Friedman test followed by Dunn's post-test. The comparison between groups for all variables will be through the unpaired t test or Mann-Whitney test, depending on data distribution. The significance level is 5%.