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Bipolar spetrun disorders in severely obese patients candidates for bariatric surgery

Grant number: 12/17498-9
Support type:Scholarships in Brazil - Master
Effective date (Start): March 01, 2013
Effective date (End): September 30, 2014
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Wang Yuan Pang
Grantee:Leorides Severo Duarte Guerra
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Background:Obesity and bipolar disorder have become major challenges to medicine. The obesity epidemic has gained global dimensions and bipolar disorder has been diagnosed with ever increasing frequency. In recent years, studies show the correlation between these pathologies.Objective: The objective of this research is to raise the frequency of bipolar spectrum disorder in patients with morbid obesity undergoing bariatric surgery. Studies indicate a high number of psychiatric disorders after surgery and bipolar disorder appears with significant frequency. Method: Patients with morbid obesity who are waiting for Bariatric Surgery, at the Hospital of Clinics, São Paulo will be submitted to specific questionnaires for psychiatric diagnosis: SCID (Structured Clinical Interview for DSM-IV Axis I Diagnosis ), HCL (Maniac Symptoms Cheklist), MDQ (Mood Disorders Questionnarie ), MADRS (Montgomery_Åsberg Depression Rating Scale-SIGMA ) e M-A QoQLII (Moorehead-Ardelt Quality of Life Questionnaire II) . Patients will be recruited consecutively from the waiting list for Bariatric Surgery Clinic - HC-FMUSP and the sample size is estimated at 400 patients. The frequency of bipolar spectrum disorders and psychiatric comorbidity pattern are calculated and correlated with psychometric scales for detecting disorders of mood and quality of life.Implications of results: Studies indicate a high number of psychiatric disorders after bariatric surgery and bipolar disorder appears with a significant frequency. Systematic reviews of obese patients with bipolar disorder and the introduction of instruments for evaluation will enable future studies to track and identify factors predictive of prognosis. Keywords: Bipolar-Disorder - Obesity - Bariatric Surgery (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DUARTE-GUERRA, LEORIDES SEVERO; COELHO, BRUNO MENDONCA; SANTO, MARCO AURELIO; LOTUFO-NETO, FRANCISCO; WANG, YUAN-PANG. Morbidity persistence and comorbidity of mood, anxiety, and eating disorders among preoperative bariatric patients. PSYCHIATRY RESEARCH, v. 257, p. 1-6, . (12/17435-7, 12/17498-9)
DUARTE-GUERRA, LEORIDES SEVERO; GORENSTEIN, CLARICE; PAIVA-MEDEIROS, PAULA FRANCINELLE; SANTO, MARCO AURELIO; NETO, FRANCISCO LOTUFO; WANG, YUAN-PANG. Clinical utility of the Montgomery-Asberg Depression Rating Scale for the detection of depression among bariatric surgery candidates. BMC Psychiatry, v. 16, . (12/18325-0, 12/17435-7, 12/17498-9)
DUARTE-GUERRA, LEORIDES SEVERO; COELHO, BRUNO MENDONCA; SANTO, MARCO AURELIO; WANG, YUAN-PANG. Psychiatric Disorders Among Obese Patients Seeking Bariatric Surgery: Results of Structured Clinical Interviews. OBESITY SURGERY, v. 25, n. 5, p. 830-837, . (12/17435-7, 12/17498-9)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GUERRA, Leorides Severo Duarte. Frequency of mental disorders among obese patients seeking bariatric surgery through the Structured Clinical Interview for DSM Disorders (SCID-I/P). 2014. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.

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