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Mechanistic Studies of Palladium/Norbornene-Catalyzed Sequential Reactions by Mass Spectrometry.

Grant number: 12/18748-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): March 01, 2013
Effective date (End): January 31, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Marcos Nogueira Eberlin
Grantee:Bruno Ricardo Vilachã Ferreira
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


This Pos-Doc project has as proposal studying the organic reactions in solution by means of mass spectrometry covering the mechanistic aspects of sequential reactions with respect to interception and characterization of transient intermediates of these processes. So one of our goals is mapping sequential reactions with the combination of certain reagents with palladium and norbornene by ESI-MS (/ MS) to evaluate the similarity with the mechanism already described in the literature by Marta Catellani and Mark Lautens for forming biaryls and heterocyclic compounds. At the same time, one also be conducting on-line monitoring of these reactions using the Ambient Ionization Source (V-EASI) based on sonic spray ionization in order to intercept novel intermediates whose half-life is extremely short and can not be detected by other techniques available in the literature. These analytical tools are used to trap and identify the species of palladium (IV) and other intermediates directly from solution into the gas phase and thereby establish the current mechanisms available in the literature and make way for new mechanistic proposals for such reactions.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA, BRUNO R. V.; CORREA, DELEON N.; EBERLIN, MARCOS N.; VENDRAMINI, PEDRO H. Fragmentation Reactions of Rhodamine B and 6G as Revealed by High Accuracy Orbitrap Tandem Mass Spectrometry. Journal of the Brazilian Chemical Society, v. 28, n. 1, p. 136-142, JAN 2017. Web of Science Citations: 4.

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