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Cardiorespiratory pattern and awake-sleep state in male and female rats exposed to fluoxetine during prenatal period

Grant number: 12/15298-2
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2013
Effective date (End): March 31, 2017
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Luciane Helena Gargaglioni Batalhão
Grantee:Vivian Biancardi Rossato
Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil
Associated research grant:08/57712-4 - The National Institute of Comparative Physiological Research, AP.TEM


Serotonin (5-HT) and noradrenaline (NE) are known to play critical roles in neurodevelopment, cardiorespiratory control and sleep-awake state and these roles may be sex-specific. 5-HT is involved in nervous maturational processes even at the fetal stage, being an important modulator of respiratory rhythm. The serotoninergic receptors 5-HT1A and 5-HT2A are found in the respiratory neurons and they play a key role in this process. Additionally, this receptors are related to hypercapnic and hypoxic responses. Early antidepressant exposure that inhibit serotonin re-uptake (SSRI) in male rats results in long-lasting behavioral effects as well as a reduction in expression of the 5-HT synthetic enzyme (tryptophan hydroxylase) in the raphe nuclei and of the 5-HT transporter (SERT) within their cortical efferent fibers. Such exposure to SSRI not only upregulates the 5-HT raphe system, but also downregulates the noradrenergic locus coeruleus (NE-LC) system since 5-HT inhibits LC function. Therefore, the goal of the present study is to evaluate the possible long-lasting effects of an exposure to SSRIs during a critical period of the development, prenatal period, on cardiorespiratory control system and sleep-awake state of male and female rats. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BIANCARDI, VIVIAN; PATRONE, LUIS GUSTAVO A.; VICENTE, MARIANE C.; MARQUES, DANUZIA A.; BICEGO, KENIA C.; FUNK, GREGORY D.; GARGAGLIONI, LUCIANE H.. Prenatal fluoxetine has long-lasting, differential effects on respiratory control in male and female rats. Journal of Applied Physiology, v. 133, n. 2, p. 19-pg., . (12/19966-0, 20/01702-2, 12/15298-2)
SCARPELLINI, CAROLINA DA SILVEIRA; CRISTINA-SILVA, CAROLINE; BIANCARDI, VIVIAN; GARGAGLIONI, LUCIANE H.; ALMEIDA, MARIA CAMILA; BICEGO, KENIA CARDOSO. Hypothalamic TRPV4 channels participate in the medial preoptic activation of warmth-defence responses in Wistar male rats. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, v. 471, n. 9, p. 1191-1203, . (12/15298-2, 15/04849-6, 11/19131-2, 17/17278-2, 15/02991-0)

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