In vitro antitumor activity of secondary metabolites obtained from the oleoresin of Copaifera duckei

• Grant number: 12/24200-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2013
• End date: December 31, 2013
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Jacqueline Campos Silva
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 11/13630-7 - Chemical and pharmacological validation of extracts and active compounds of Copaifera species, AP.TEM

Abstract

Despite the wide folk use of copaiba oil resin by the Brazilians since the XIX century and several developed studies corroborating many of its ethnopharmacological uses, as well as its production being around 800 tons per year, there is a great need to fully determine the following parameters: phytochemical, pharmacological, toxicological and clinical studies, aiming to guarantee safety, efficacy, and quality, which are mandatory for developing new phytomedicines. In this sense, the goal of this proposal is to undertake a phytochemical study with the oleoresin of Copaifera duckie and to evaluate the antitumor activity (in vitro) of the major secondary metabolites isolated from this natural source, aiming to better understand the use of oleoresin from species of Copaifera by the Brazilian population as antitumoral agents.(AU)