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Association of genetic polymorphisms of extracellular matrix metalloproteinase 2 with arterial stiffness and left ventricular hypertrophy in resistant hypertension

Grant number: 12/23419-4
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): April 01, 2013
Effective date (End): August 31, 2016
Field of knowledge:Biological Sciences - Pharmacology
Principal Investigator:Heitor Moreno Junior
Grantee:Andréa Rodrigues Sabbatini
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


Resistant hypertension (RH) is characterized by high blood pressure in spite of concurrent use of three antihypertensive agents of different classes, combined at optimal doses and including a diuretic. Indeed, RH includes patients with controlled blood pressure using four or more agents. Resistant hypertensive patients have an unfavorable prognostic and the morbidity and mortality occur in consequence of the high prevalence of target-organ damage in these patients, including left ventricular hypertrophy and arterial stiffness. Metalloproteinases (MMPs) are a family of enzymes that degrade extracellular matrix proteins and are involved in cardiovascular remodeling related to target-organ damage in cardiovascular diseases, including hypertension (HT). Several studies in experimental models and in humans showed increased levels of MMP-2 in HT. However, there is no study in resistant hypertension showing the role of MMP-2 in target-organ damage in this group of patients. The aim of this study is to evaluate the association of the levels and activity of MMP-2 and your inhibitor TIMP-2 (tissue inhibitors of metalloproteinases), and how the polymorphisms in these enzyme (MMP-2 -1575G>A; MMP-2 -1306C>T; MMP-2 -735C>T) affect the left ventricular hypertrophy, arterial stiffness and other phenotypes of the RH and HT diseases.

Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
SABBATINI, Andréa Rodrigues. Effects of MMP-2 and TIMP-2 levels and -1575 G/A; -1306 C/T and -735 C/T MMP-2 polymorphisms in resistant hypertension. 2016. Doctoral Thesis - Universidade Estadual de Campinas, Faculdade de Ciências Médicas.

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