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Analysis of different times of bone healing in normal and osteopenic female rats subjected to immobilization

Grant number: 13/02542-5
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): October 31, 2014
Field of knowledge:Engineering - Biomedical Engineering
Principal researcher:Antônio Carlos Shimano
Grantee:Aline Goulart de Paiva
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Osteoporosis is a serious public health problem. With increasing life expectancy of the population, it is estimated that in 2050 a total of 6.26 million fractured neck of femur will occur due to low bone density in the world. The understanding of bone healing in osteoporotic individuals is essential, since the timing of immobilization for these patients is still unknown. Therefore, the object of this study is to analyze the effects of different times of immobilization on bone healing in osteopenic rats. Will be used 40 Wistar rats were divided into four groups (SHAM2; GO2; SHAM6; GO6). The animals in groups and GO2 GO6 be subject to suspension by the tail skeletal traction for 3 weeks for installation of osteopenia, the groups SHAM2 and SHAM6 not be suspended, but kept in cages for this period. Will be realized right tibia osteotomy total, and after the surgery, the hind limbs rights are immobilized . After immobilization time the animals are euthanized and the right tibias dissected and analyzed for densitometric, histomorphometric and mechanical.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PAIVA, A. G.; YANAGIHARA, G. R.; MACEDO, A. P.; RAMOS, J.; ISSA, J. P. M.; SHIMANO, A. C. Analysis of fracture healing in osteopenic bone caused by disuse: experimental study. Brazilian Journal of Medical and Biological Research, v. 49, n. 3 MAR 2016. Web of Science Citations: 0.

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