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Mathematical modelling of cellulolitic enzymes production by filamentous fungi in submerse fermentation

Grant number: 12/19271-1
Support type:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): July 31, 2014
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Aline Carvalho da Costa
Grantee:Lucas Gelain
Home Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:08/57873-8 - An integrated process for total bioethanol production and zero CO2 emission, AP.BIOEN.TEM


The development of processes for the use of lignocellulosic materials is still a great challenge nowadays. In order to convert biomass to biofuels or other chemicals the hydrolysis must occur with high yields. Although enzymatic hydrolysis has some significant advantages, its use is limited by the high costs associated to the production of the cellulolytic complex. In order to make the second generation ethanol production viable it is essential to improve enzymes production. The minimization of the production costs involves the screening of microorganisms capable of high production of the essential enzymes, as well as the optimization of the production in large scale. This requires that mathematical models are available to enable the understanding of the phenomena and to be used to optimization and process scale-up. The objective of this work is to study the mathematical modeling of the production of cellulases by filamentous fungi. To accomplish this task, experimental assays will be performed, a mathematical model will be proposed and the kinetic parameters will be estimated using non-linear estimation techniques.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GELAIN, LUCAS; DA CRUZ PRADELLA, JOSE GERALDO; DA COSTA, ALINE CARVALHO. Mathematical modeling of enzyme production using Trichoderma harzianum P49P11 and sugarcane bagasse as carbon source. Bioresource Technology, v. 198, p. 101-107, DEC 2015. Web of Science Citations: 2.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
GELAIN, Lucas. Mathematical modeling of enzymes production using Trichoderma harzianum in submerse fermentation and sugarcane bagasse as carbon source. 2014. Master's Dissertation - Universidade Estadual de Campinas. Faculdade de Engenharia Química.

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