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Medicinal Chemistry of Carbazole Alkaloids: Synthesis of claurailas and analogs targeting new antileishmanial compounds

Grant number: 13/00727-8
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): May 01, 2013
Effective date (End): January 31, 2015
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Flavio da Silva Emery
Grantee:Fernando Fumagalli
Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


The leishmaniasis is a neglected disease that affects millions of people worldwide, mainly in tropical countries. This disease is caused by Leishmania spp., and has two clinical form: cutaneous and visceral. Currently there are few therapeutic options for this disease, and the search for new drugs has been the subject of research. In this scenario recent studies showed carbazoles alkaloids active against Leishmania donovani. The carbazole Clauraila A, recently isolated and with antitumor activity already described, is an interesting subject to search against leishmaniasis, since have a very similar chemical structure of Lansine, a carbazole active against Leishmania. Combining the active potential of carbazoles and molecular modification techniques, this work aims at the synthesis of natural compound Clauraila A and active analogues against the parasite Leishmania, evaluating the relationship between chemical structure and biological activity of these compounds.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA. Pd(II)-mediated cyclodehydrogenation of formyldiarylamines-total synthesis of natural carbazoles clauraila A, clausenal and 6-methoxymurrayanine. Tetrahedron Letters, v. 56, n. 18, p. 2307-2310, . (12/20990-2, 13/00727-8)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FUMAGALLI, Fernando. Carbazole alkaloids chemistry: synthesis of Claurailas and library of analogues. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas de Ribeirão Preto (PCARP/BC) Ribeirão Preto.

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