This project proposes to develop methodologies for standardization of herbal extracts that may be applicable in the treatment of chronic diseases (ulcerative lesions, and inflammatory colitis). It is intended to develop analytical strategies that will allow qualitative and quantitative standardization of a plant extract, including identification of classes of substances, chemical markers and / or the active principles. As an object of study, will address the chemical-pharmacological a species native to northeastern Brazil and widely spread in the states of São Paulo and Minas Gerais: Mimosa caesalpiniifolia Benth. (Mimosoideae). This species is used for chronic respiratory problems, wound healing and inflammatory processes and showed promising results for anticancer activity, anti-inflammatory and antimicrobial. The studies involve 70% EtOH extracts of different organs (leaves, bark and roots), prepared according to pharmacopoeial standards. After pharmacological and toxicological evaluation, the leaf extracts are standardized according to standards. The work will be transdisciplinary, with participants from various campus UNESP (Laboratory of Biodiversity and Sustainability of Experimental Paulista Campus, Institute of Chemistry Araraquara, Faculty of Pharmaceutical Sciences of Araraquara, Biosciences Institute at Botucatu and others).
News published in Agência FAPESP Newsletter about the scholarship: