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Asymmetry in the Parkinson Disease: effects on walking and posture

Grant number: 12/24040-9
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2013
Effective date (End): March 31, 2014
Field of knowledge:Health Sciences - Physical Education
Principal researcher:Lilian Teresa Bucken Gobbi
Grantee:Fabio Augusto Barbieri
Home Institution: Instituto de Biociências (IB). Universidade Estadual Paulista (UNESP). Campus de Rio Claro. Rio Claro , SP, Brazil

Abstract

The most patients with Parkinson's disease (PD) shows unilateral motor impairment. However, the motor control related to asymmetry on walking and postural control is not well known. The general aim of this study will be to analyze the asymmetry on walking, with and without environmental demands, and posture, according to the effect of medication, of the patients with PD in early and moderate stages of the disease. To answer the questions of the project, two studies will be developed, which will address the asymmetry on walking with and without auditory cue and postural control in different static positions. Thirty patients with PD, who will be to distribute in two groups according to stage of the disease, and 15 neurologically healthy individuals will participate in the study. The participants will perform clinical evaluation: stage of the disease, PD degree of involvement, and cognitive conditions; motor evaluation: coordination, strength and range of motion; walking evaluation: it will be assessed spatiotemporal and kinetic parameters, analyzing the asymmetry between the sides during the tasks; posture evaluation: it will be evaluated postural control in bipedal support, tandem position, and unipedal support, comparing the asymmetry between the limbs. The PD patients will perform the evaluations in "ON" and "OFF" state of the medication. The clinical data will be compared using nonparametric tests. The data related to motor tests, walking and postural parameters will be compared through MANOVAs according independent variables of the study.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BARBIERI, FABIO AUGUSTO; CARPENTER, MARK; BERETTA, VICTOR SPIANDOR; ORCIOLI-SILVA, DIEGO; SIMIELI, LUCAS; VITORIO, RODRIGO; BUCKEN GOBBI, LILIAN TERESA. Postural control, falls and Parkinson's disease: Are fallers more asymmetric than non-fallers?. HUMAN MOVEMENT SCIENCE, v. 63, p. 129-137, FEB 2019. Web of Science Citations: 1.
BERETTA, VICTOR SPIANDOR; BARBIERI, FABIO AUGUSTO; ORCIOLI-SILVA, DIEGO; ROCHA DOS SANTOS, PAULO CEZAR; SIMIELI, LUCAS; VITORIO, RODRIGO; BUCKEN GOBBI, LILIAN TERESA. Can Postural Control Asymmetry Predict Falls in People With Parkinson's Disease?. MOTOR CONTROL, v. 22, n. 4, p. 449-461, OCT 2018. Web of Science Citations: 2.
BARBIERI, FABIO A.; POLASTRI, PAULA F.; BAPTISTA, ANDRE M.; LIRANI-SILVA, ELLEN; SIMIELI, LUCAS; ORCIOLI-SILVA, DIEGO; BERETTA, VICTOR S.; GOBBI, LILIAN T. B. Effects of disease severity and medication state on postural control asymmetry during challenging postural tasks in individuals with Parkinson's disease. HUMAN MOVEMENT SCIENCE, v. 46, p. 96-103, APR 2016. Web of Science Citations: 6.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.