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Evaluation of Bone Mineral Density in Postmenopausal Breast Cancer Survivors

Grant number: 13/02671-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): June 01, 2013
Effective date (End): May 31, 2014
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Eliana Aguiar Petri Nahás
Grantee:Michelle Sako Omodei
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Breast cancer is the second most common type of cancer worldwide and the most prevalence among women. Long follow-up is recommended after the diagnosis and treatment of breast cancer, and with age the risk of co-morbidities increases. Current anticancer strategies have contributed to the increase of cancer survivors and in some cases the cancer becomes a "chronic disease". Studies indicate that breast cancer survivors are at high risk for cardiovascular disease, diabetes and osteoporosis; admittedly a vulnerable population. Osteoporosis affects more than 200 million people worldwide and is most prevalent in Caucasian women. In the early years postmenopausal, in response to hypoestrogenism, occurs rapid loss of bone mass. The decline in bone mineral density (BMD) and structural integrity results in increased risk for osteoporosis in women. The major clinical consequence of osteoporosis is fracture, which occurs mainly in femoral neck, spine and wrist. There are five times higher prevalence of vertebral fractures in breast cancer survivors of when compared to women of similar age. The vertebral or hip fractures are associated with a 20% increase in mortality rate. Recognizing the risk for reduced BMD and the consequences on quality of life, is imperative a program to promote bone health for breast cancer survivors. The overall objective of the study is to evaluate BMD in postmenopausal breast cancer survivors followed at Botucatu Medical School, UNESP. And the specific objectives: 1 - To study the occurrence of low bone mineral density in postmenopausal breast cancer survivors 2 - to investigate the most influential risk factors for low bone mineral density in breast cancer survivors compared to those without breast cancer. Methods: This is clinical, analytical and comparative study. Will be included in the study group women with: (1) date of last menstrual period for at least 12 months and age > 45 years, (2) histological diagnosis of breast cancer, (3) have completed treatment with surgery, radiotherapy, chemotherapy and hormone therapy (when indicated), (4) be free of disease for at least five years, (5) non-alcoholic and non-addicted. The control group in a 1:2 ratio controls, will consist of women with last menstrual period for at least 12 months and age >45 years without breast cancer and matched by age. Will be collected through interviews, clinical data regarding osteoporosis risk, anthropometry, DEXA, and, data on breast cancer. It is hoped that the findings can assist in knowledge about the pattern of BMD in this special group of patients and identify women at high risk for osteoporotic fracture assisting in improving follow-up and conduct in clinical practice, affecting significantly the quality of life of postmenopausal breast cancer survivors.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PRISCILA FERREIRA POLONI; MICHELLE SAKO OMODEI; JORGE NAHAS-NETO; GILBERTO UEMURA; HELOISA DE LUCA VÉSPOLI; ELIANA AGUIAR PETRI NAHAS. Prevalência da baixa densidade mineral óssea em mulheres na pós-menopausa tratadas de câncer de mama. Revista Brasileira de Ginecologia e Obstetrícia, v. 37, n. 1, p. 30-35, Jan. 2015.

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