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Association between dietary intake, metabolic profile and oxidative stress in psoriasis and psoriatic arthritis patients

Grant number: 12/18789-7
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): June 01, 2013
Effective date (End): August 31, 2014
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Marcelo de Medeiros Pinheiro
Grantee:Beatriz Figueiredo Leite
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil


Psoriasis (Ps) and psoriatic arthritis (PA) are associated with increased risk of metabolic syndrome (MetS), adiposity and cardiovascular mortality. In all these conditions there, the increase of oxidative stress and inflammation is recognized as one of the main mechanisms involved. However, the influence of diet in these diseases are not well established. Objectives: To compare the nutritional and metabolic profile of patients with Ps and AP activity. Patients and methods: 94 patients will be included with Ps and 94 patients with AP, through cross-sectional study. Patients with liver, lung and kidney diseases will be excluded, as well as those in previous nutritional treatment or use of anabolic drugs and consumption of protein supplements, vitamins or antioxidants. The characteristics of the disease and risk factors for MetS, as well as details of concomitant diseases and medications associated will be evaluated by a standard questionnaire. Food intake will be studied by the three-day food record, including a day of the weekend, and daily energy intake, macro and micronutrients will be calculated using the program NDSR. Furthermore, anthropometric data will be verified, physical activity and body composition (DXA, GE-Lunar DPX-MD +). The cutoff proposed by the IDF (2006) will be used for the classification of MetS. The activity and disease severity will be evaluated using the PASI (Psoriasis Area Severity Index), DAS28 (Disease Activity Score) and HAQ (Health Assessment Questionnaire). In addition, biochemical analyzes include anti-LDL and anti-LDLoxidada, insulin, adiponectin, apolipoprotein A and B,AGEs. For statistical analysis, will be used mean and standard deviation, Kolmogorov-Smirnov test, Student's t test, Pearson correlation, chi-square or Fisher's exact test. The value of significance is p <0.05.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEITE, BEATRIZ F.; MORIMOTO, MELISSA A.; GOMES, CARINA M. F.; KLEMZ, BARBARA N. C.; GENARO, PATRICIA S.; SHIVAPPA, NITTIN; HEBERT, JAMES R.; DAMASCENO, NAGILA R. T.; PINHEIRO, MARCELO M.. Dietetic intervention in psoriatic arthritis: the DIETA trial. ADVANCES IN RHEUMATOLOGY, v. 62, n. 1, p. 12-pg., . (12/18789-7, 12/18701-2)
LEITE, BEATRIZ FIGUEIREDO; MORIMOTO, MELISSA APARECIDA; GOMES, CARINA; DE CARVALHO KLEMZ, BARBARA NASCIMENTO; GENARO, PATRICIA DE SOUZA; TEIXEIRA DAMASCENO, NAGILA RAQUEL; SZEJNFELD, VERA LUCIA; PINHEIRO, MARCELO DE MEDEIROS. Higher bodily adiposity, fat intake, and cholesterol serum levels are associated with higher disease activity in psoriatic arthritis patients: is there a link among fat and skin and joint involvement?. LIPIDS IN HEALTH AND DISEASE, v. 19, n. 1, . (12/18789-7, 12/18701-2)

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