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Analysis of the association between the components of evoked auditory potential of long latency and cardiac autonomic regulation during the hearing test in healthy men

Grant number: 12/19775-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2013
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Physiology - General Physiology
Principal Investigator:Vitor Engrácia Valenti
Grantee:Viviane Borim de Góes
Host Institution: Faculdade de Filosofia e Ciências (FFC). Universidade Estadual Paulista (UNESP). Campus de Marília. Marília , SP, Brazil


The electrical changes that occur in the peripheral and central auditory systems before the acoustic or electric stimuli are analyzed by the evoked auditory potential of long latency (PEALL). This method quantifies the neural and electrical activity in areas of the central auditory pathway. The central nervous system also regulates the cardiovascular system. In this context, heart rate variability (HRV) is a method that analyzes cardiac autonomic control. It raises the possibility that some components of the PEALL may be related to the HRV indices. Objective: To investigate the association between components of PEALL and indexes of HRV during the hearing test in men. Method: The study will be conducted in adults, healthy young males between 18 and 30 years old. The HRV will be examined during the hearing test and the following HRV indices will be analyzed: the time domain: SDNN (standard deviation of all normal RR intervals), RMSSD (square root of the mean squared differences between adjacent normal RR intervals), and pNN50 (percentage of adjacent RR intervals with a difference of greater than 50ms duration); frequency domain: LF (low frequency) and HF (high frequency). We will analyze the following PEALL components: N1 (P100), P2 (P200), N2 (N200), and P3 (P300). Will apply the Pearson correlation test for parametric distributions and the Spearman correlation test for non-parametric distributions to evaluate the association between components of PEALL and HRV indices. (AU)

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