|Support type:||Scholarships in Brazil - Master|
|Effective date (Start):||June 01, 2013|
|Effective date (End):||February 28, 2015|
|Field of knowledge:||Health Sciences - Physiotherapy and Occupational Therapy|
|Principal researcher:||Marilza Vieira Cunha Rudge|
|Grantee:||Ana Paula Machado de Almeida|
|Home Institution:||Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil|
Gestational Diabetes Mellitus, characterized by glucose intolerance of variable intensity, firstly detected during pregnancy, has been identified as a risk factor for urinary incontinence. The collagen has a essencial role for urinary continence. The literature shows that in urinary incontinence occurrence, the gene expression of proteins was altered as well as increased activity of MMPs. The type 1 and 3 collagen polymorphism also have been investigated because it influences the occurrence of urinary incontinence. This paper is appropriate because there is a necessity of new investigations about possible influencing factors in the urinary continence and integrity of pelvic floor muscle. This paper aims at analyzing the relationship between type 3 collagen and metalloproteinase 9 polymorphism and urinary incontinence in women with Gestational Diabetes Mellitus. We will analyze approximately 300 women, selected through manipulation from the Prenatal Clinic. Women who gave birth between 2009 and 2012, as well as pregnant women between the 34th and 38th week of gestation by the time of collection and that meet the inclusion criteria will be included in the study. The collection will include the use of an evaluation form, a questionnaire about quality of life for women with urinary incontinence, a questionnaire to quantify and qualify the urinary loss and another questionnaire about sexual response in pregnancy, anthropometric measurements and collection of saliva samples. The statistical analysis as well as the tests to compare variables and groups will be chosen according to the results, characteristics and behavior of the variables. The analysis of retrospectively data will be made separately and together.