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Molecular bases of endocytosis and cell death induced by biosynthetic silver nanoparticles in breast cancer cells

Grant number: 13/05432-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2013
Effective date (End): April 30, 2014
Field of knowledge:Biological Sciences - Biochemistry
Principal Investigator:Marcelo Bispo de Jesus
Grantee:Gustavo Oliveira Pugliese
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Nanotechnology applications have been touted as a promising source of new solutions for medicine, mainly because it constitutes a new perspective in the search for alternative therapies for some diseases. For example, there are few efficient therapies for the treatment of late-stage breast cancer. Thus, the recently discovered silver nanoparticles synthetized by fungi have been considered as one potential alternative for the breast cancer treatment. This proposal seeks to understand the endocytotic pathways by which breast cancer cells (MCF-7 line) internalize silver nanoparticles. In addition, it proposes to study the intracellular processing of biosynthetic silver nanoparticles, i.e. autophagy, apoptosis and oxidative stress in breast tumor cells. The study of the endocytic pathway of silver nanoparticles in breast cancer cell, followed by the understanding of their biological processes will able us to evaluate the therapeutic potential of these nanoparticles for advanced stages of the breast tumor.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ALLAN RADAIC; GUSTAVO OLIVEIRA PUGLIESE; GUILHERME CAPIRAÇO CAMPESE; FRANCISCO BENEDITO TEIXEIRA PESSINE; MARCELO BISPO DE JESUS. COMO ESTUDAR INTERAÇÕES ENTRE NANOPARTÍCULAS E SISTEMAS BIOLÓGICOS. Química Nova, v. 39, n. 10, p. 1236-1244, Dez. 2016.

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