| Grant number: | 12/13577-1 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | June 01, 2013 |
| End date: | July 31, 2015 |
| Field of knowledge: | Biological Sciences - Morphology - Anatomy |
| Principal Investigator: | Maria Julia Marques |
| Grantee: | Adriana Fogagnolo Mauricio |
| Host Institution: | Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil |
Abstract In Duchenne Muscular Dystrophy (DMD) and in the mdx mice, model of DMD, lack of dystrophin leads to skeletal and cardiac muscle loss, fibrosis and progressive cardiorespiratory failure. Biomarkers for DMD have been widely investigated to follow up the evolution of the disease, facing the new pharmacological, genetics and cellular therapies to DMD. In the present study, by using metabolomic analysis of the cardiac and diaphragm muscles of the mdx, we aim to identify new biomarkers that can be correlated to heart and / or diaphragm dystrophinopathy, at later stages of the disease. We will use omega-3, an anti-inflammatory drug that had been proven effective in protecting dystrophic skeletal muscle against myonecrosis, as a tool to validate the potential new biomarkers here described. Additionally, we will investigate the effects of omega-3 in mdx cardiomyopathy. Overall, with the present study we will add a new technique (metabolomics) for the analysis of dystrophic muscle in our laboratory that we hope will help searching new molecules that can better signal the progress of the pathology in skeletal and cardiac muscles, and further support the use of omega-3 as an additional therapy. (AU) | |
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