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Isolation and identification of secondary metabolites from Plantago catharinea (Plantaginaceaee) leaves

Grant number: 13/07681-3
Support type:Scholarships abroad - Research Internship - Scientific Initiation
Effective date (Start): September 10, 2013
Effective date (End): January 09, 2014
Field of knowledge:Biological Sciences - Botany - Applied Botany
Principal researcher:Maria Bernadete Gonçalves Martins
Grantee:Leonardo Mendes de Souza Mesquita
Supervisor abroad: Sonia Piacente
Home Institution: Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil
Research place: Università degli Studi di Salerno, Italy  
Associated to the scholarship:11/23113-0 - Plantago Secretory Structures: structural morphology and chemical - a leaf compared study, BP.IC


Species of plants containing bioactive substances are increasingly subject of research, leading to alternative therapeutic treatments or revealing substances that can be exploited to produce pharmaceuticals. Thus, phytochemical analysis are so much important, due to the large number of secondary metabolites that can be found. Plantago catharinea (Plantaginaceae) is from restinga ecosystems, specifically beaches and dunes. Coastal plants have high pharmaceutical potential, because it operate in an environment with poor nutrients due to saline soil and unstable, moreover, are exposed to high air temperatures and soil that lead to stress, interfering with the production of metabolites such as terpenoids, flavonoids and alkaloids. These constraints make the plants sandbank potential sources of substances for producing pharmaceuticals. Plantago catharinea is known by popular name of "Tanchagem" and has a similar morphology with species Plantago tomentosa and Plantago australis, which are also used in traditional medicine and known by the same popular name. Although P. catharinea be used as medicine, little is known about their chemical composition as well as its pharmacological activity, to prove its effectiveness. Thats a intense use as medicinal species "tanchagem" in Brazil (P. major, P. australis, P. lanceolata, P. ovata), proposes to the phytochemical study of P. catharinea, since it can be a potential source of biologically active metabolites, in addition to being a rare and endangered. For this, the study will be shared by two stages (I) Pharmacognostic step - drying, milling and standardization of plant material and (ii) chemical step - extraction, chromatographic screening, isolation and identification of metabolites. In this context, the results obtained with these experiments will contribute to the understanding of the chemical composition of the species, in addition facilitating studies with others of the same gender, which are being studied in parallel in the research project linked (proc # 2011/23113-0: Secretory structures of Plantago: Structural morphology chemistry - a compared leaf study). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE SOUZA MESQUITA, LEONARDO MENDES; DA ROCHA, CLAUDIA QUINTINO; LIMA AFFONSO, LUIZ HENRIQUE; CERULLI, ANTONIETTA; PIACENTE, SONIA; PEREIRA TANGERINA, MARCELO MARUCCI; GONCALVES MARTINS, MARIA BERNADETE; VILEGAS, WAGNER. Phenolic Isomers from Plantago catharinea Leaves: Isolation, Identification, Quantification and in vitro Antioxidant Activity. NATURAL PRODUCT COMMUNICATIONS, v. 12, n. 3, p. 409-412, MAR 2017. Web of Science Citations: 1.

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