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EEG-fMRI in the pre-operatory evaluation of patients with focal refractory epilepsies

Grant number: 13/00099-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2013
Effective date (End): September 30, 2015
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Fernando Cendes
Grantee:Ana Carolina Coan
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID
Associated scholarship(s):14/04266-8 - EEG-fMRI in refractory epilepsies: evaluation of its use in highly complex cases and comparison with invasive monitoring, BE.EP.PD

Abstract

About 30% of patients with focal epilepsy have epileptic seizures refractory to antiepileptic drugs and for them the best treatment is the surgical removal of the ictal onset zone. The preoperative evaluation of patients with focal refractory epilepsy is a procedure that requires high financial resources and that may involve significant risk of morbidity if invasive procedures are necessary. Moreover, even with detailed preoperative assessment, prognosis of seizure control in the long term after surgery is very heterogeneous, with over 50% of individuals with seizure recurrence after 10 years. Concomitant use of electroencephalogram associated with functional magnetic resonance imaging (EEG-fMRI) allows noninvasive evaluation of simultaneous neuronal activity and cerebral hemodynamics. This technique can be an effective and less costly alternative for determining the ictal onset zone in individuals with focal refractory epilepsies. EEG-fMRI is being used today in research on epilepsy. The aim of this study is to evaluate the contribution of the technique of EEG-fMRI in the preoperative evaluation of patients with focal refractory epilepsies.

Scientific publications (7)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, D. S.; COAN, A. C.; AVELAR, W. M. Neuropsychological and neuroimaging evidences of cerebral dysfunction in stroke-free patients with atrial fibrillation: A review. JOURNAL OF THE NEUROLOGICAL SCIENCES, v. 399, p. 172-181, APR 15 2019. Web of Science Citations: 1.
AVANSINI, SIMONI H.; TORRES, FABIO R.; VIEIRA, ANDRE S.; DOGINI, DANYELLA B.; ROGERIO, FABIO; COAN, ANA C.; MORITA, MARCIA E.; GUERREIRO, MARILISA M.; YASUDA, CLARISSA L.; SECOLIN, RODRIGO; CARVALHO, BENILTON S.; BORGES, MURILO G.; ALMEIDA, VANESSA S.; ARAUJO, PATRICIA A. O. R.; QUEIROZ, LUCIANO; CENDES, FERNANDO; LOPES-CENDES, ISCIA. Dysregulation of NEUROG2 plays a key role in focal cortical dysplasia. ANNALS OF NEUROLOGY, v. 83, n. 3, p. 623-635, MAR 2018. Web of Science Citations: 3.
SILVA, DANILO S.; AVELAR, WAGNER M.; DE CAMPOS, BRUNNO M.; LINO, ANA PAULA B. L.; BALTHAZAR, MARCIO L. F.; FIGUEIREDO, MARCIO J. O.; CENDES, FERNANDO; COAN, ANA CAROLINA. Default Mode Network Disruption in Stroke-Free Patients with Atrial Fibrillation. CEREBROVASCULAR DISEASES, v. 45, n. 1-2, p. 78-84, 2018. Web of Science Citations: 1.
AVANSINI, SIMONI H.; DE SOUSA LIMA, BEATRIZ PEREIRA; SECOLIN, RODRIGO; SANTOS, MARILZA L.; COAN, ANA CAROLINA; VIEIRA, ANDRE S.; TORRES, FABIO R.; CARVALHO, BENILTON S.; ALVIM, MARINA K. M.; MORITA, MARCIA E.; YASUDA, CLARISSA L.; PIMENTEL-SILVA, LUCIANA R.; DOGINI, DANYELLA B.; ROGERIO, FABIO; CENDES, FERNANDO; LOPES-CENDES, ISCIA. MicroRNA hsa-miR-134 is a circulating biomarker for mesial temporal lobe epilepsy. PLoS One, v. 12, n. 4 APR 6 2017. Web of Science Citations: 10.
DE CAMPOS, BRUNNO MACHADO; COAN, ANA CAROLINA; YASUDA, CLARISSA LIN; CASSEB, RAPHAEL FERNANDES; CENDES, FERNANDO. Large-Scale Brain Networks Are Distinctly Affected in Right and Left Mesial Temporal Lobe Epilepsy. Human Brain Mapping, v. 37, n. 9, p. 3137-3152, SEP 2016. Web of Science Citations: 28.
ALVIM, MARINA K. M.; COAN, ANA C.; CAMPOS, BRUNNO M.; YASUDA, CLARISSA L.; OLIVEIRA, MARIANA C.; MORITA, MARCIA E.; CENDES, FERNANDO. Progression of gray matter atrophy in seizure-free patients with temporal lobe epilepsy. Epilepsia, v. 57, n. 4, p. 621-629, APR 2016. Web of Science Citations: 14.
CAMPOS, BRUNNO M.; COAN, ANA C.; BELTRAMINI, GUILHERME C.; LIU, MIN; YASSUDA, CLARISSA L.; GHIZONI, ENRICO; BEAULIEU, CHRISTIAN; GROSS, DONALD W.; CENDES, FERNANDO. White matter abnormalities associate with type and localization of focal epileptogenic lesions. Epilepsia, v. 56, n. 1, p. 125-132, JAN 2015. Web of Science Citations: 22.

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