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Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations

Grant number: 13/04806-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2013
Effective date (End): June 30, 2017
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Antonio Herbert Lancha Junior
Grantee:Vitor de Salles Painelli
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Carnosine is a cytoplasmic dipeptide found in abundance in skeletal muscle. The pH buffering is the best function attributed to carnosine. Cross-sectional studies have shown that athletes engaged in high-intensity, short duration exercises have a higher muscle carnosine content compared to untrained and physically active subjects, supporting the role of carnosine as a buffer, and suggesting that exercise training could modulate the dipeptide intramuscular concentrations. However, the longitudinal studies investigating the effect of exercise training on muscle carnosine content did not observe any effects of this intervention. It is speculated that the lack of dietary control, as well as the use of low intensity and/or duration exercise protocols are potential causes for the lack of effect of exercise training on intramuscular carnosine. Therefore, our group aims to investigate the effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations. For this purpose, approximately 20 vegetarians volunteers will be recruited, matched for maximal aerobic capacity (VO2máx) and randomly assigned to the Trained (T - n = 10) or Non-Trained (NT - n = 10) group. Before (PRE) and after (POST) the training period, volunteers will undergo a muscle biopsy procedure of the vastus lateralis to assess the intramuscular content of carnosine. Additionally, at PRE and POST volunteers will also undergo a cardiopulmonary exercise test for assessment of physical capacity and VO2máx. Furthermore, they will also be submitted to an assessment of body composition by hydrostatic weighing. The inferential analysis will be conducted by independent T-test and analysis of variance for mixed model with SAS. The level of significance will be p <0.05. (AU)

Scientific publications (17)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOLAN, EIMEAR; SWINTON, PAUL A.; PAINELLI, VITOR DE SALLES; HEMINGWAY, BENEDICT STEPHENS; MAZZOLANI, BRUNA; SMAIRA, FABIANA INFANTE; SAUNDERS, BRYAN; ARTIOLI, GUILHERME G.; GUALANO, BRUNO. A Systematic Risk Assessment and Meta-Analysis on the Use of Oral beta-Alanine Supplementation. ADVANCES IN NUTRITION, v. 10, n. 3, p. 452-463, MAY 2019. Web of Science Citations: 0.
BASSINELLO, DIOGO; PAINELLI, VITOR DE SALLES; DOLAN, EIMEAR; LIXANDRAO, MANOEL; CAJUEIRO, MONIQUE; DE CAPITANI, MARIANA; SAUNDERS, BRYAN; SALE, CRAIG; ARTIOLI, GUILHERME G.; GUALANO, BRUNO; ROSCHEL, HAMILTON. Beta-alanine supplementation improves isometric, but not isotonic or isokinetic strength endurance in recreationally strength-trained young men. Amino Acids, v. 51, n. 1, p. 27-37, JAN 2019. Web of Science Citations: 0.
DA SILVA, RAFAEL PIRES; DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; KRATZ, CAROLINE DE ANDRADE; PAINELLI, VITOR DE SALLES; SILVA, VINICIUS DA EIRA; BOUZAS MARINS, JOAO CARLOS; FRANCHINI, EMERSON; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. Effects of -alanine and sodium bicarbonate supplementation on the estimated energy system contribution during high-intensity intermittent exercise. Amino Acids, v. 51, n. 1, p. 83-96, JAN 2019. Web of Science Citations: 0.
PAINELLI, VITOR DE SALLES; NEMEZIO, KLEINER MARCIO; PINTO, ANA JESSICA; FRANCHI, MARIANA; ANDRADE, ISABEL; RIANI, LUIZ AUGUSTO; SAUNDERS, BRYAN; SALE, CRAIG; HARRIS, ROGER CHARLES; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. High-Intensity Interval Training Augments Muscle Carnosine in the Absence of Dietary Beta-alanine Intake. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 50, n. 11, p. 2242-2252, NOV 2018. Web of Science Citations: 1.
OLIVEIRA, L. F.; DE SALLES PAINELLI, V.; NEMEZIO, K.; GONCALVES, L. S.; YAMAGUCHI, G.; SAUNDERS, B.; GUALANO, B.; ARTIOLI, G. G. Chronic lactate supplementation does not improve blood buffering capacity and repeated high-intensity exercise. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 27, n. 11, p. 1231-1239, NOV 2017. Web of Science Citations: 3.
SAUNDERS, B.; DE OLIVEIRA, L. F.; DA SILVA, R. P.; DE SALLES PAINELLI, V.; GONCALVES, L. S.; YAMAGUCHI, G.; MUTTI, T.; MACIEL, E.; ROSCHEL, H.; ARTIOLI, G. G.; GUALANO, B. Placebo in sports nutrition: a proof-of-principle study involving caffeine supplementation. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, v. 27, n. 11, p. 1240-1247, NOV 2017. Web of Science Citations: 18.
GONCALVES, LIVIA DE SOUZA; PAINELLI, VITOR DE SALLES; YAMAGUCHI, GUILHERME; DE OLIVEIRA, LUANA FARIAS; SAUNDERS, BRYAN; DA SILVA, RAFAEL PIRES; MACIEL, ERIKA; ARTIOLI, GUILHERME GIANNINI; ROSCHEL, HAMILTON; GUALANO, BRUNO. Dispelling the myth that habitual caffeine consumption influences the performance response to acute caffeine supplementation. Journal of Applied Physiology, v. 123, n. 1, p. 213-220, JUL 2017. Web of Science Citations: 27.
SAUNDERS, BRYAN; PAINELLI, VITOR DE SALLES; DE OLIVEIRA, LUANA FARIAS; SILVA, VINICIUS DA EIRA; DA SILVA, RAFAEL PIRES; RIANI, LUIZ; FRANCHI, MARIANA; GONCALVES, LIVIA DE SOUZA; HARRIS, ROGER CHARLES; ROSCHEL, HAMILTON; ARTIOLI, GUILHERME GIANNINI; SALE, CRAIG; GUALANO, BRUNO. Twenty-four Weeks of beta-Alanine Supplementation on Carnosine Content, Related Genes, and Exercise. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, v. 49, n. 5, p. 896-906, MAY 2017. Web of Science Citations: 16.
KRATZ, CAROLINE DE ANDRADE; PAINELLI, VITOR DE SALLES; DE ANDRADE NEMEZIO, KLEINER MARCIO; DA SILVA, RAFAEL PIRES; FRANCHINI, EMERSON; ZAGATTO, ALESSANDRO MOURA; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI. Beta-alanine supplementation enhances judo-related performance in highly-trained athletes. JOURNAL OF SCIENCE AND MEDICINE IN SPORT, v. 20, n. 4, p. 403-408, APR 2017. Web of Science Citations: 4.
DE ARAUJO DIAS, GABRIELA FROIO; SILVA, VINICIUS DA EIRA; PAINELLI, VITOR DE SALLES; SALE, CRAIG; ARTIOLI, GUILHERME GIANNINI; GUALANO, BRUNO; SAUNDERS, BRYAN. (In) Consistencies in Responses to Sodium Bicarbonate Supplementation: A Randomised, Repeated Measures, Counterbalanced and Double-Blind Study. PLoS One, v. 10, n. 11 NOV 17 2015. Web of Science Citations: 11.
LANCHA JUNIOR, ANTONIO HERBERT; PAINELLI, VITOR DE SALLES; SAUNDERS, BRYAN; ARTIOLI, GUILHERME GIANNINI. Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise. SPORTS MEDICINE, v. 45, n. 1, p. S71-S81, NOV 2015. Web of Science Citations: 15.
SOLIS, MARINA YAZIGI; COOPER, SIMON; HOBSON, RUTH M.; ARTIOLI, GUILHERME G.; OTADUY, MARIA C.; ROSCHEL, HAMILTON; ROBERTSON, JACQUES; MARTIN, DANIEL; PAINELLI, VITOR S.; HARRIS, ROGER C.; GUALANO, BRUNO; SALE, CRAIG. Effects of Beta-Alanine Supplementation on Brain Homocarnosine/Carnosine Signal and Cognitive Function: An Exploratory Study. PLoS One, v. 10, n. 4 APR 14 2015. Web of Science Citations: 8.
PAINELLI, VITOR DE SALLES; ALVES, VICTOR TAVARES; UGRINOWITSCH, CARLOS; BENATTI, FABIANA BRAGA; ARTIOLI, GUILHERME GIANNINI; LANCHA, JR., ANTONIO HERBERT; GUALANO, BRUNO; ROSCHEL, HAMILTON. Creatine supplementation prevents acute strength loss induced by concurrent exercise. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY, v. 114, n. 8, p. 1749-1755, AUG 2014. Web of Science Citations: 8.
PAINELLI, VITOR DE SALLES; DA SILVA, RAFAEL PIRES; DE OLIVEIRA JUNIOR, ODILON MARQUES; DE OLIVEIRA, LUANA FARIAS; BENATTI, FABIANA BRAGA; RABELO, TOBIAS; LIMONGI FRANCA GUILHERME, JOAO PAULO; LANCHA JUNIOR, ANTONIO HERBERT; ARTIOLI, GUILHERME GIANNINI. The Effects of Two Different Doses of Calcium Lactate on Blood pH, Bicarbonate, and Repeated High-Intensity Exercise Performance. INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, v. 24, n. 3, p. 286-295, JUN 2014. Web of Science Citations: 3.
PAINELLI, VITOR DE SALLES; SAUNDERS, BRYAN; SALE, CRAIG; HARRIS, ROGER CHARLES; SOLIS, MARINA YAZIGI; ROSCHEL, HAMILTON; GUALANO, BRUNO; ARTIOLI, GUILHERME GIANNINI; LANCHA, JR., ANTONIO HERBERT. Influence of training status on high-intensity intermittent performance in response to beta-alanine supplementation. Amino Acids, v. 46, n. 5, p. 1207-1215, MAY 2014. Web of Science Citations: 21.
SOLIS, MARINA YAZIGI; ARTIOLI, GUILHERME GIANNINI; MONTAG, EDUARDO; PAINELLI, VITOR DE SALLES; SAITO, FABIO LOPES; LIMA, FERNANDA RODRIGUES; ROSCHEL, HAMILTON; GUALANO, BRUNO; LANCHA JUNIOR, ANTONIO HERBERT; BENATTI, FABIANA BRAGA. The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2014. Web of Science Citations: 5.

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