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Analysis of chimeric promoter induced by zinc of the celobiohydrolase I from Trichoderma reesei

Grant number: 13/10015-5
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2013
Effective date (End): June 30, 2014
Field of knowledge:Biological Sciences - Microbiology
Principal Investigator:Felipe Santiago Chambergo Alcalde
Grantee:Filipe Guimarães Graça
Home Institution: Escola de Artes, Ciências e Humanidades (EACH). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The filamentous fungus Trichoderma reesei presents an efficient protein secretion machinery which makes it an excellent organism for large-scale production of homologous or heterologous proteins with industrial application. Our proposal aims at the analysis of chimeric promoter, induced by zinc, of the cellobiohydrolase I gene from T. reesei, to evaluate its potential use to drive expression of recombinant proteins of interest. This will produce the necessary enzymes for biomass hydrolysis with consequent reduction of its cost, contributing to the spread of the use of biomass as a source for biofuels. (AU)