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Using the technique of nuclear magnetic resonance in investigation of metabolic profile from breast cancer cells subjected to chemotherapy.

Grant number: 13/05128-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): December 01, 2013
Effective date (End): November 30, 2016
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Luiz Alberto Colnago
Grantee:Roberta Manzano Maria
Host Institution: Embrapa Instrumentação Agropecuária. Empresa Brasileira de Pesquisa Agropecuária (EMBRAPA). Ministério da Agricultura, Pecuária e Abastecimento (Brasil). São Carlos , SP, Brazil

Abstract

Breast cancer is the second leading cause of women death worldwide. Despite the effectiveness improvement in the last decade of drugs used in this disease treatment, there are still many cases of intolerance and failure. This is because diseased cells can adapt themselves and survive the therapies used, leading to drug resistance. In addition, chemotherapy may have a less effective activity in some patients, according to genetic factors, age and environmental factors.Thus, there is still a great information requirement of all aspects about the mode of drugs action in genomic, proteomic, transcriptomic and metabolomic levels. During DSc, the candidate has developed high resolution NMR methods to analyze metabolites in breast cancer cells. The main purpose of post-doctoral is the application of these nuclear magnetic resonance - NMR techniques to evaluate the effect of three drugs used in breast cancer chemotherapy (doxorrubicin, tamoxifen and statins), in both healthy and tumor cells metabolism. Namely, this means NMR application to trace pathways of tumor and healthy cells during chemotherapy, thus helping to elucidate the metabolic effects of these medicaments.

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROBERTA M. MARIA; WANESSA F. ALTEI; NAPOLEÃO F. VALADARES; RICHARD C. GARRATT; ADRIANO D. ANDRICOPULO; TIAGO VENÂNCIO; LUIZ A. COLNAGO. Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by H HR-MAS NMR Spectroscopy. Journal of the Brazilian Chemical Society, v. 30, n. 1, p. 3-7, . (13/05128-5, 09/17846-4)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA S.; COLNAGO, LUIZ A.. Effects of Doxorubicin, Cisplatin, and Tamoxifen on the Metabolic Profile of Human Breast Cancer MCF-7 Cells As Determined by H-1 High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance. BIOCHEMISTRY, v. 56, n. 16, p. 2219-2224, . (13/00798-2, 13/05128-5)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; ANDRICOPULO, ADRIANO D.; BECCENERI, AMANDA B.; COMINETTI, MARCIA R.; VENANCIO, TIAGO; COLNAGO, LUIZ A.. Characterization of metabolic profile of intact non-tumor and tumor breast cells by high-resolution magic angle spinning nuclear magnetic resonance spectroscopy. Analytical Biochemistry, v. 488, p. 14-18, . (09/17846-4, 13/05128-5)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; VALADARES, NAPOLEAO F.; GARRATT, RICHARD C.; ANDRICOPULO, ADRIANO D.; VENANCIO, TIAGO; COLNAGO, LUIZ A.. Effect of cis-9, trans-11 Conjugated Linoleic Acid (CLA) on the Metabolism Profile of Breast Cancer Cells Determined by H-1 HR-MAS NMR Spectroscopy. Journal of the Brazilian Chemical Society, v. 30, n. 1, p. 3-7, . (13/05128-5, 09/17846-4)
MARIA, ROBERTA M.; ALTEI, WANESSA F.; SELISTRE-DE-ARAUJO, HELOISA S.; COLNAGO, LUIZ A.. Impact of chemotherapy on metabolic reprogramming: Characterization of the metabolic profile of breast cancer MDA-MB-231 cells using H-1 HR-MAS NMR spectroscopy. Journal of Pharmaceutical and Biomedical Analysis, v. 146, p. 324-328, . (13/00798-2, 13/05128-5)

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