Structural and Thermodynamic studies of proteins, surfactants and protein complexes

• Grant number: 13/09604-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: October 01, 2013
• End date: September 30, 2015
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Cristiano Luis Pinto de Oliveira
• Grantee: Sun Yang
• Host Institution: Instituto de Física (IF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 11/13616-4 - Optical and structural properties of elastomers and complex fluids of biological interest, AP.TEM

Abstract

In this project it is presented the research proposal for Dr. Sun Yang, to be developed at the Institute of Physics,University of São Paulo. Dr. Sun is going to work on the Complex Fluids Group, under the supervision of Prof. Dr.Cristiano L. P. Oliveira, also collaborating with the other professors from that group in several projects. As will bepresented, Dr. Sun will develop his research on the studies of protein-protein interactions and protein-surfactantsapplications. His advanced skills on fluorescence techniques will permit a unique combination with complementarystructural and calorimetric studies applied to the study of aggregation behavior of casein micelles. The knowledgeof Dr. Sun will certainly contribute for the development of other research areas inside of the group like the studyof complexes between proteins with several types of surfactants and investigation of lipid membranes complexedwith DNA molecules. In both cases fluorescence techniques provides important information regarding bindingprocesses and dynamics, permitting a better comprehension of the system.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SUN, YANG; ZHANG, JUNTAO; WANG, HAIBO; WANG, TINGTING; CHENG, HUA; YU, BO; OLIVEIRA, CRISTIANO L. P.. Sulfate dodecyl sodium-induced stability of a model intrinsically disordered protein, bovine casein. FOOD HYDROCOLLOIDS, v. 82, p. 19-28, SEP 2018. (13/09604-6, 15/01732-0)

SUN, YANG; OSELIERO FILHO, PEDRO L.; OLIVEIRA, CRISTIANO L. P.. alpha-Lactalbumin and sodium dodecyl sulfate aggregates: Denaturation, complex formation and time stability. FOOD HYDROCOLLOIDS, v. 62, p. 10-20, JAN 2017. (13/09604-6)

SUN, YANG; OSELIERO FILHO, PEDRO L.; SONG, YANG; WANG, ZHICHUN; JI, HANG; OLIVEIRA, CRISTIANO L. P.. The role of hydrophobic interactions in the molten globule state of globular protein modulated by surfactants. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 230, p. 11-pg., 2023-10-01. (13/09604-6)