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Study of HLA-G molecules in the soluble form in the cerebrospinal fluid and serum from patients with multiple Sclerosis

Grant number: 13/06168-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2013
Effective date (End): July 31, 2014
Field of knowledge:Biological Sciences - Immunology
Principal researcher:CARLOS OTÁVIO BRANDÃO
Grantee:Amanda de Barros Piffer
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Multiple sclerosis (MS) is a chronic, autoimmune disease that affects the central nervous system in young adults. The disease may evolve from a clinical episode isolated (CIS) to form remittent/recurrent and after about ten years, to a form secondary progressive MS. The disease is caused by inflammation and neurodegeneration that normally occurs simultaneously in all phases of the disease. The inflammation predominates in remitting phase/recurrent, whereas the neurodegeneration predominate in the secondary progressive phase of the disease. In the phase remittent/recurrent autoreactive CD4 T lymphocytes play an prominent role in the mechanisms of demyelination. Simultaneously, mechanisms that regulate the immune response are activated. Cells of the innate immune response such as dendritic can express immunoregulatory molecules as molecules HLA-G that negatively regulated the response of lymphocytes autoreactive. In this proposal is our purpose to investigate how treatment Interferon beta alters the expression of HLA-G both present on the cell surface, as well as in the soluble form in serum and cerebrospinal fluid of patients with MS.

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