Preparation and Reactivity of Chiral Iodine(III) Compounds

• Grant number: 13/06218-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Effective date (Start): August 01, 2013
• Effective date (End): June 30, 2014
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Luiz Fernando da Silva Júnior
• Grantee: Livia Nunes Cavalcanti
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

A series of new hypervalent iodine(III) compounds will be preparedin situ, including those derived from peptides and from poli-methylated iodo arenes. These compounds will be tested mainly in ring contraction reactions, aiming the synthesis of diverse cyclic compound optically active. Other reactions, such as ±-oxy-tosiloxylation and spiro lactonization will also be tested, thus increasing the scope of the methodology.