Citotoxity activity of CD4+ encephalitogenic lymphocytes in Experimental Autoimmune Encephalomyelitis

• Grant number: 13/10637-6
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2013
• End date: July 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Alessandro dos Santos Farias
• Grantee: Guilherme Antonio Dutra Morais
• Host Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 11/18728-5 - Study of migratory, effector and regulatory pattern of autoreactive t lymphocytes, previously transduced with GFP in experimental demyelinating diseases, AP.JP

Abstract

The Experimental Autoimmune Encephalomyelitis (EAE) is the experimental model for human Multiple Sclerosis (MS). The EAE has been helping to understand the inflamatory mechanisms of the MS and to test and develop new drugs. The inflamatory response during EAE is characterized by mononuclear cells infiltration in the central nervous system (CNS) and, consequently, destruction of myelin. The EAE can be transfered to healthy animals by the injection of T CD4+ lymphocytes previously sensibilized with CNS mielin components. However, little is known about how these cells iniciate the inflamatory process. Our preliminary data show that these autoreactive T CD4+ lymphocytes have a high expression of cytotoxic molecules like granzimes B; C and perforin. These cytotoxic molecules expression could explain the direct action of the autoreactive T CD4+ lymphocytes on the demyelination caused by the inflamatory process on EAE. Therefore, our aim is to better evaluate these molecules expression during the clinical evolution of the disease and their role in the generation and mainteance of the autoreactive response during EAE.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MORAIS, Guilherme Antonio Dutra. Encephalitogenic T CD4+ cells build a cytotoxic profile during the evolution of experimental autoimmune encephalomyelitis and become CD8alphabeta+. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.