Comparative study of propofol doses in the anesthesia induction of the obese dog

• Grant number: 13/15643-4
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2013
• End date: September 30, 2015
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Silvia Renata Gaido Cortopassi
• Grantee: Fernanda Correa Devito
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity is the most common nutritional disease of our time and may alter the pharmacokinetics of the general anesthetics, due changes that it cause in the animal body. Medical studies have shown that dosing propofol according to lean body mass in the anesthesia induction of the obese human avoids overdose and side undesirable effects like apnea and arterial hypotension. In veterinary medicine, propofol is the most widely used general anesthetic for induction of anesthesia and there is no much information about the anesthetic doses used in obese dog. The objective of this study is to compare the quality of anestesia induction by calculating the dose of propofol based on lean body weight with the dose of propofol based on the total body weight in obese dogs (body score e 8 and percentage of total body fat more than 30%). Sixty dogs will be used and divided into three groups: Group 1 or control (CON) - composed by 20 animals with ideal bod condition score, Group 2 (LBW) - composed by 20 obese animals whose dose of propofol used will be based on the lean body weight and group 3 (TBW) - also composed by 20 obese dogs and in this group the propofol dose will be based on total body weight. The body composition of all dogs will be determined by the technique of deuterium isotopes dilution. The anestesia quality of anesthesia in the three groups will be evaluated through the use of variables. Parametric statistical tests and nonparametric will be used to analyze the results and for comparison between the groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DEVITO, FERNANDA CORREA; FONSECA PATRICIO, GENI CRISTINA; FLOR, PATRICIA BONIFACIO; ANNIBALE VENDRAMINI, THIAGO HENRIQUE; AMARAL, ANDRESSA RODRIGUES; PFRIMER, KARINA; BRUNETTO, MARCIO ANTONIO; GAIDO CORTOPASSI, SILVIA RENATA. Comparative study of anaesthesia induction in obese dogs using propofol dosages based on lean body weight or total body weight. VETERINARY AND ANIMAL SCIENCE, v. 10, DEC 2020. (13/15643-4)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

DEVITO, Fernanda Correa. Comparative study of propofol doses in the anesthesia induction of the obese dog. 2015. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) São Paulo.