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Central and peripheral changes on energy balance in rats submitted to resistance training and exposed to nandrolone decanoate

Grant number: 13/05549-0
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): October 01, 2013
Effective date (End): September 30, 2016
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Vânia D'Almeida
Grantee:Renan Pozzi
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Energy balance is a complex phenomenon, which mechanism involves central and peripheral actions of hormones and neuropeptides. The physical exercise is directly related at this mechanism by orexigenic and anorexigenic neurons modulation. Nowadays, some bodybuilders, athletes and physical exercise´s practitioners has been using anabolic androgenic steroids to obtain improved performance or esthetic. However, the chronic use of these substances is associated with a higher collateral effects and metabolism alteration. The aim of this study will be evaluate changes in central and peripheral hormones and neuropeptides related to energy balance in rats submitted to resistance training and exposed to nandrolone decanoate. A total of 40 mice will be distributed in four groups: Group I: control; Group II: resistive exercise group; Group III: exposed to nandrolone decanoate group; Group IV: submitted to resistance exercise associated and exposed to nandrolone decanoate. After the experimental periods, the animals will be euthanized and their brains, organs and peripheral blood will be collected for analysis of hormones and neuropeptides serum concentration for biochemical assays and gene expression by qPCR.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
POZZI, RENAN; FERNANDES, LEANDRO; DA SILVA, VANESSA CAVALCANTE; D'ALMEIDA, VANIA. Nandrolone decanoate and resistance exercise affect body composition and energy metabolism. Steroids, v. 174, . (13/05549-0, 13/17587-4)

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