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Secondary metabolites of two species of guaco (Mikania glomerata Sprenguel and Mikania laevigata Schultz) grown under varied conditions.

Grant number: 13/15962-2
Support type:Scholarships in Brazil - Master
Effective date (Start): October 01, 2013
Effective date (End): August 31, 2015
Field of knowledge:Biological Sciences - Botany - Applied Botany
Principal researcher:Alexandra Christine Helena Frankland Sawaya
Grantee:Claudia de Lazzari Almeida
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The use of medicinal plants and phytotherapic medicine is being increasingly stimulated by government policies at all levels. Syrup based on Mikania glomerata presently furnished by the Brazilian Health System (SUS) as medicine for cough and bronchitis. However, variations in the cultivation conditions of medicinal plants may result in different concentrations of active components, affecting the safety, quality and efficiency expected of herbal medicines. Few studies regarding the cultivation of the two species of interest as medicinal plants, Mikania glomerata e Mikania laevigata Schultz, were found. To this moment, the fluctuations in the concentrations of secondary metabolites in these species due to environmental variations have not been satisfactorily evaluated. As both species are found in the 1st Brazilian Phytotherapic Formulary, and apparently may be used indiscriminately, they shall be studied in parallel. We will evaluate how the secondary metabolites are influenced by variations in the following cultivation conditions: temperature, luminosity, soil fertility and pH; and mechanical damage. After the treatments, the extracts of the leaves will be evaluated by liquid chromatography-mass spectrometry, following the differences in the concentration of their chemical marker, coumarin, and the profile of the other components, as well as the levels of chlorophyll, starch and sugars. These results will allow us to determine the best conditions for these two species to be grown in order to minimize the variations in contents of active substances; and may be used as a standard condition for the cultivation these medicinal plants.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BORGHI, ALEXANDRE A.; ALMEIDA, CLAUDIA DE L.; SAWAYA, ALEXANDRA C. H. F. Damage and drying modify the composition of Mikania glomerata and Mikania laevigata leaves. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 29, n. 6, p. 793-797, NOV-DEC 2019. Web of Science Citations: 0.
ALMEIDA, CLAUDIA DE LAZZARI; HELENA FRANKLAND SAWAYA, ALEXANDRA CHRISTINE; LOPEZ DE ANDRADE, SARA ADRIAN. Mycorrhizal influence on the growth and bioactive compounds composition of two medicinal plants: Mikania glomerata Spreng. and Mikania laevigata Sch Bip. ex Baker (Asteraceae). BRAZILIAN JOURNAL OF BOTANY, v. 41, n. 1, p. 233-240, MAR 2018. Web of Science Citations: 0.
ALMEIDA, CLAUDIA DE LAZZARI; XAVIER, RENATA MOURA; BORGHI, ALEXANDRE AUGUSTO; DOS SANTOS, VIVIAN FRANCESCHINI; HELENA FRANKLAND SAWAYA, ALEXANDRA CHRISTINE. Effect of seasonality and growth conditions on the content of coumarin, chlorogenic acid and dicaffeoylquinic acids in Mikania laevigata Schultz and Mikania glomerata Sprengel (Asteraceae) by UHPLC-MS/MS. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, v. 418, n. SI, p. 162-172, JUL 2017. Web of Science Citations: 8.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ALMEIDA, Claudia de Lazzari. Secondary metabolites of two species of guaco (Mikania glomerata Sprengel and Mikania laevigata Schultz) grown under varied conditions. 2015. Master's Dissertation - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia.

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