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Clinical and microbiological effects of aPDT compared with systemic amoxicillin/ metronidazole in the treatment of chronic periodontitis in smokers: a randomized controlled study

Grant number: 13/05424-3
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): November 01, 2013
Effective date (End): June 30, 2015
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Letícia Helena Theodoro
Grantee:Naida Zanini Assem
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Clinical and microbiological effects of aPDT compared with systemic Amoxicillin/ Metronidazole in the treatment of chronic periodontitis in smokers: a randomized controlled study.The aim of this study will be evaluate the clinical and microbiological effects of scaling and root planing (SRP) combined with Metronidazole and Amoxicillin (MTZ+AMX) or antimicrobial photodynamic therapy (aPDT) in the treatment of smokers with chronic periodontitis. A double-blind controlled, randomized clinical trial will be conducted in 51 patients who will receive: Group SRP (n=17) - scaling and root planning; Group MTZ+AMX (n=17) - SRP combined with Metronidazole (400 mg 3 X per day 7 days) and Amoxicillin (500 mg 3 X per day 7 days); Group aPDT (n=17) - SRP combined with aPDT in pockets e 4 mm (baseline, 48 and 72 hs). Clinical and microbiologic examination will be performed at baseline, 3 and 6 months post-therapy. Clinical parameters of visible plaque index, bleeding on probing, probing depth, gingival recession and clinical attachment level will be measured. Microbiologic subgingival samples will be taken from deepest pockets in group SRP, MTZ+AMX and group aPDT, in pockets e 4 mm treated with aPDT. The aPDT will be performed using a methylene blue and a low level laser therapy after 1 minute (GaAlAs, 660 nm, 100mW, 48 seconds, 157 J/cm2), immediately, 48 and 72 hours pos-treatment. Five periodontal pathogens will be quantified by real time polymerase chain reaction: Porphyromonas gingivalis (Pg), Tannerella forsythensis (Tf), Aggregatibacter actinomycetemcomitans (Aa), Prevotella nigrescens (Pn) and Prevotella intermedia (Pi). The clinical and microbiological data will be statistically analyzed (± = 5%). (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
THEODORO, LETICIA HELENA; ASSEM, NAIDA ZANINI; LONGO, MARIELLEN; FERRO ALVES, MARCIO LUIZ; DUQUE, CRISTIANE; STIPP, RAFAEL NOBREGA; VIZOTO, NATALIA LEAL; GARCIA, VALDIR GOUVEIA. Treatment of periodontitis in smokers with multiple sessions of antimicrobial photodynamic therapy or systemic antibiotics: A randomized clinical trial. Photodiagnosis and Photodynamic Therapy, v. 22, p. 217-222, . (13/05424-3)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
ASSEM, Naida Zanini. Estudo comparativo do uso da terapia fotodinâmica antimicrobiana (aPDT) com uso sistêmico de amoxicilina e metronidazol, no tratamento da periodontite crônica em pacientes fumantes. 2015. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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