Drug addiction is gaining dramatic aspects in terms of its dimensions and the undesirable effects. These chemicals agents can reduce immune reactivity and tissue repair, enhancing microbial aggression, aggravating the periodontal destruction and other side effects. This study aims to assess the presence of major periodontal pathogens in the mouth of drug addiction patients, in comparison with individuals who do not present this chemical dependency, as well as assessing whether oral conditions could affect the occurrence of such microorganisms. Thus, data on systemic health and socioeconomic conditions, drug abuse were obtained from 100 patients with drug addiction kept in rehabilitation program and an equal number of non-dependents who constitute the control group. Intra and extraoral clinical examinations were performed and samples of supragingival and subgingival biofilm, saliva and mucous membranes were collected. The presence of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, P. loescheii, P. nigrescens, Tannerella forsythia, and Treponema denticola will be assessed by polymerase chain reaction (PCR) using specific primers and amplification conditions. Odds ratios will be calculated to determine the risk factors for periodontal infections and the multivariate logistic regression will be used to evaluate the possibility of inter-relationships between the clinical and microbiological parameters.
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