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Inactivation of hydrogen peroxide used in bleaching procedure: influence of the quantity, concentration and application form of antioxidants in the depth of penetration of the peroxide under simulated intrapulpal pressure.

Grant number: 12/18829-9
Support Opportunities:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2013
Effective date (End): May 31, 2015
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Rosa Helena Miranda Grande
Grantee:Eugenio Jose Garcia
Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The oxidative stress of hydrogen peroxide is considered the main cause of sensitive teeth by bleaching. The products currently used to treat tooth sensitivity may be considered nonspecific since they do not operate in directly inactivating the free radicals from the peroxide. The use of specific products, or antioxidants, would be a suitable option for this purpose. This project aims to define through in vitro studies: 1) define the amount of antioxidants (sodium fluoride, potassium nitrate, vitamin E, vitamin C and sodium ascorbate) required to inactivate hydrogen peroxide used in bleaching, 2) evaluate if penetration of hydrogen peroxide 35% in the pulp chamber of human teeth, is influenced after use of antioxidants under simulated intrapulpar pressure and, 3) analyzing the effect of concentration (1, 5 and 10%) and as application (active and passive) of antioxidants in their penetration into the pulp chamber of human teeth under intrapulpar pressure.

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