Effect of aerobic exercise training on inflammatory infiltrating tumor in cachectic na non-cachectic patients

• Grant number: 13/17734-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2013
• End date: October 31, 2015
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Marilia Cerqueira Leite Seelaender
• Grantee: Reinaldo Abunasser Bassit
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 12/50079-0 - Systemic inflammation in cachectic cancer patients: mechanisms and therapeutical strategies, a translational medicine approach, AP.TEM

Abstract

Epidemiologic evidence indicates a strong association between regular exercise (training) and low incidence of cancer. Animal studies suggest that physical training or voluntary physical activity increases resistance to experimentally induced tumor growth and can be used as adjunctive therapy for some patients with muscle loss associated with low functional capacity, two main features presented by patients with cancer. The cachexia caused by cancer manifests itself in more than two thirds of patients affected by the disease, and the total of tissue mass loss (muscle and fat) can reach 80%, a factor that is closely linked to the high mortality rate (50 % of patients). Recent studies confirm a strong association between cancer and inflammation, as evidenced by lower susceptibility to the disease with the use of nonsteroidal anti-inflammatory drug. In contrast, overweight or obese have a higher incidence of tumors, mainly due to the inflammatory state of adipose tissue. In fact, the inflammatory state may be associated directly or indirectly with cancer. It is known that exercise induces increased systemic levels of a number of substances, mainly cytokines with anti-inflammatory properties. In addition, regular physical training is capable of enhancing the capacity and functionality of the immune system to avoid and / or preventing the onset of diseases, including cancer. However, the mechanisms involved in the functionality of immune cells infiltrate the tumor in relation to the stimulus of chronic exercise, and participation in the containment or reduction in tumor size as well as the possible effect on the decrease of the same malignancy remains a reply to be explored. In view of the tumor infiltrating cells and the action of the same regression caused by physical training, is in our interest to investigate the effect of exercise on these cells in the tumor microenvironment. As is known, the immune infiltration of the tumor is able to modulate the rate of progression and invasiveness of the cancer, so our proposal is to investigate the effect of physical training on this cell population, since this strategy proven to reduce systemic inflammation and cachexia associated with cancer, and consistently has reduced tumor in animal model.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MARZUCA-NASSR, G. N.; FORTES, M. A. S.; GUIMARAES-FERREIRA, L.; MURATA, G. M.; VITZEL, K. F.; VASCONCELOS, D. A. A.; BASSIT, R. A.; CURI, R.. Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension. Brazilian Journal of Medical and Biological Research, v. 52, n. 10, 2019. (13/17734-7)