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Analysis of matrix metalloproteinases expression in satellite glial cells of the trigeminal ganglion of rats with persistent temporomandibular joint inflammation undergoing low level lasertherapy.

Grant number: 13/15588-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2013
Effective date (End): January 31, 2016
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Christie Ramos Andrade Leite Panissi
Grantee:Amanda de Carvalho Desiderá
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Pain is the main symptom can to lead individuals to seek medical and dental treatment. In dentistry it is estimated that about 40-75% of the population suffering with orofacial pain and has at least one sign or symptom of temporomandibular disorders (TMD). The TMD represents a multifactorial pathology and affects the temporomandibular joint and masticatory muscles, causing pain in the orofacial region as well as changes in oral motions. The main sign of this disease is joint inflammation, which causes pain related structures. The inflammation leads to release of mediators such as substance P, CGRP, TNF-± and IL-². These mediators are able to sensitize free nerve endings and the nociceptive information walks to first central station, the trigeminal ganglion. When persistent inflammation leads to expression of matrix metalloproteinases (MMP), which promotes the action of means of modulating the perception of pain, and satellite glial cells (CSGs), the main structures involved in the nociceptive perception modulation. Moreover, non-invasive therapies are sought to mitigate efficient pain symptoms arising from TMD, LLLT is shown as an effective treatment, but the dose-dependent effect generates ambiguous results. In this context, the aim this work to verify inflammatory biomarkers present in synovial fluid in rats with persistent inflammation of the TMJ, as well as identify whether MMPs act on the CSGs or neurons, by immunohistochemistry. (AU)

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