Effects of aversive stimulation on the catalepsy caused by intraperitoneal administration of haloperidol

• Grant number: 13/19280-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: November 01, 2013
• End date: February 28, 2014
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Amanda Ribeiro de Oliveira
• Grantee: Nayara Cobra Barreiro Barroca
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

The modulatory effect of haloperidol on the nigrostriatal dopaminergic pathway induces catalepsy, a behavioral state in which the subject is not able to correct externally imposed postures. This cataleptic state is often used in animal models of the motor impairments observed in Parkinson's disease. One of the symptoms of Parkinson's disease is the bradykinesia, which appears to be dependent on the emotional state of the patients, suggesting that patients with Parkinson's disease have the motor system intact but find it difficult to access it without an external stimulus. For example, some immobile patients are able to make quick movements after hearing the cry "fire". A recent study suggests that interference in the neural substrates of the inferior colliculus (IC) - which is a structure primarily involved in the processing of auditory information, but also linked to structures of the motor system and of the brain aversion system - can influence haloperidol-induced catalepsy. Thus, considering that the IC has connections that are related to the motor control of catalepsy, and connections with the brain aversion system, we want to assess whether an aversive emotional state can exert some influence on the catalepsy caused by intraperitoneal administration of haloperidol. For this, catalepsy tests will be performed associated with the exposure of rats to different types of aversive stimulation: exposure of the animals to an open-field test, to footshocks, and finally to psychological stress represented by the contextual conditioned fear test.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BARROCA, NAYARA C. B.; GUARDA, MARIANA D.; DA SILVA, NAIARA T.; COLOMBO, ANA C.; REIMER, ADRIANO E.; BRANDAO, MARCUS L.; DE OLIVEIRA, AMANDA R.. Influence of aversive stimulation on haloperidol-induced catalepsy in rats. Behavioural Pharmacology, v. 30, n. 2-3, p. 10-pg., 2019-04-01. (16/13141-0, 13/19280-3, 16/04620-1, 16/05544-7)

BARROCA, NAYARA C. B.; GUARDA, MARIANA D.; DA SILVA, NAIARA T.; COLOMBO, ANA C.; REIMER, ADRIANO E.; BRANDAO, MARCUS L.; DE OLIVEIRA, AMANDA R.. Influence of aversive stimulation on haloperidol-induced catalepsy in rats. Behavioural Pharmacology, v. 30, n. 2-3, SI, p. 229-238, APR 2019. (16/04620-1, 16/13141-0, 16/05544-7, 13/19280-3)